João Guilherme

João Guilherme may refer to:


 * Choco (footballer, born 4 January 1990), João Guilherme Estevão da Silva, Brazilian former football forward
 * João Guilherme (footballer, born 1986), João Guilherme Leme Amorim, Brazilian football defender
 * João Guilherme (footballer, born 1994), João Guilherme Barcelos Neto Nogueira, Brazilian football forward
 * João Guilherme Ripper (born 1959), Brazilian composer
 * João Guilherme Fischer (1876–1952), Brazilian diplomat
 * João Sousa (footballer, born 1994), João Guilherme Gonçalves de Sousa, Portuguese football defender