Joro toxin

Joro spider toxin (joro toxin, JSTX) – a toxin which was originally extracted from the venom of the joro spider (Trichonephila clavata), originally native to Japan.

Biochemical analysis
Joro toxin has demonstrated the ability to selectively block It inhibits
 * postsynaptic glutamate potentials and
 * AMPA glutamate receptors.
 * NMDA receptors in the CNS of vertebrates.

Joro toxin does not affect
 * aspartate-induced neural depolarization,
 * resting membrane potential,
 * nerve terminal spontaneous signalling, or
 * inhibitory postsynaptic potentials.