List of Billboard Hot 100 top-ten singles in 2021

This is a list of singles that charted in the top ten of the Billboard Hot 100, an all-genre singles chart, in 2021.

Top-ten singles
Key
 * – indicates single's top 10 entry was also its Hot 100 debut
 * – indicates Best performing song of the year
 * (#) – 2021 Year-end top 10 single position and rank
 * The "weeks in top ten" column reflects each song's entire chart life, not just its run during 2021.