List of Houston Astros no-hitters

The Houston Astros (formerly known as the Houston Colt .45s from 1962–1964) are a Major League Baseball franchise based in Houston, Texas. Formed in 1962, they play in the American League West division (formerly in the National League Central division until 2012). Pitchers for the Astros have thrown seventeen no-hitters in franchise history, the most of all of MLB's expansion teams added since 1961. A no-hitter is officially recognized by Major League Baseball only "when a pitcher (or pitchers) allows no hits during the entire course of a game, which consists of at least nine innings", though one or more batters "may reach base via a walk, an error, a hit by pitch, a passed ball or wild pitch on strike three, or catcher's interference". No-hitters of less than nine complete innings were previously recognized by the league as official; however, several rule alterations in 1991 changed the rule to its current form. No perfect games, a special subcategory of no-hitter, have been thrown in Astros history. As defined by Major League Baseball, "in a perfect game, no batter reaches any base during the course of the game."

Don Nottebart threw the first no-hitter in Astros history on May 17, 1963; the most recent no-hitter was thrown by Ronel Blanco on April 1, 2024. Only 1 left-handed starting pitcher (Framber Valdez) has thrown a no-hitter in franchise history. The longest interval between no-hitters was 12 years, 2 months and 10 days from the combined no-hitter led by Roy Oswalt on June 11, 2003, and that thrown by Fiers on August 21, 2015. The shortest interval was just 29 days from the combined no-hitter led by Sanchez on August 3, 2019, and Verlander's no-hitter on September 1. They no-hit the Cincinnati Reds, the Los Angeles Dodgers, the New York Yankees, the Philadelphia Phillies, and the Toronto Blue Jays the most, which occurred twice. There are three no-hitters in which the team allowed at least a run, by Nottebart in 1963, Johnson in 1964 (which was a 9-inning home loss), and Kile in 1993. The most baserunners allowed in a no-hitter was by Wilson (in 1969), who allowed eight. Twelve no-hitters were thrown at home, and five on the road. The Astros have thrown three no-hitters in April, two in May, three in June, one in July, three in August, four in September, and one in November. Of the seventeen no-hitters, four have been won by a score of 2–0, more common than any other result. The largest margin of victory in a no-hitter was a 10–0 win by Blanco in 2024. The smallest margin of victory was 2–0 wins by Wilson in 1967, Mike Scott in 1986, Verlander in 2019, and Valdez in 2023.

Jose Altuve holds the modern-day record of most no-hitters participated in with one team at seven.

The umpire is also an integral part of any no-hitter. The task of the umpire in a baseball game is to make any decision “which involves judgment, such as, but not limited to, whether a batted ball is fair or foul, whether a pitch is a strike or a ball, or whether a runner is safe or out… [the umpire’s judgment on such matters] is final.” Part of the duties of the umpire making calls at home plate includes defining the strike zone, which "is defined as that area over homeplate (sic) the upper limit of which is a horizontal line at the midpoint between the top of the shoulders and the top of the uniform pants, and the lower level is a line at the hollow beneath the kneecap." These calls define every baseball game and are therefore integral to the completion of any no-hitter. A different umpire presided over each of the franchise’s seventeen no-hitters.

The manager is another integral part of any no-hitter. The tasks of the manager include determining the starting rotation as well as batting order and defensive lineup every game. Nine different managers have involved in the franchise’s seventeen no-hitters.