List of Major League Baseball players from Panama

This is an alphabetical list of baseball players from Panama who played in Major League Baseball between and. The first Panamanian ever to appear in the Majors was Humberto Robinson.

Current
Major League Baseball
 * Edmundo Sosa in Philadelphia Phillies
 * José Caballero in Seattle Mariners
 * Miguel Amaya in Chicago Cubs
 * Christian Bethancourt in Tampa Bay Rays
 * Jaime Barría in Los Angeles Angels
 * Justin Lawrence in Colorado Rockies
 * Javy Guerra in Tampa Bay Rays
 * Ivan Herrera in St. Louis Cardinals

Current
Minor League Baseball
 * Jonathan Arauz
 * Johan Camargo
 * Allen Córdoba
 * Randall Delgado
 * José Ramos
 * Paolo Espino
 * Ariel Jurado
 * Rubén Tejada
 * Darío Agrazal

Former

 * Ed Acosta
 * Manny Acosta
 * Manuel Barrios
 * Juan Berenguer
 * Christian Bethancourt
 * Enrique Burgos (born 1965)
 * Enrique Burgos (born 1990)
 * Rod Carew
 * Ossie Chavarria
 * Ángel Chávez
 * Bruce Chen
 * Webbo Clarke
 * Manny Corpas
 * Roger Deago
 * Luis Durango
 * Einar Díaz
 * Mike Eden
 * Gil Garrido
 * Severino González
 * Bill Haywood
 * Tom Hughes
 * Roberto Kelly
 * Carlos Lee
 * Allan Lewis
 * Héctor López
 * José Macías
 * Carlos Maldonado
 * Rafael Medina
 * Ramiro Mendoza
 * Orlando Miller
 * Omar Moreno
 * Julio Mosquera
 * Ivan Murrell
 * Sherman Obando
 * Ben Oglivie
 * Adolfo Phillips
 * Bobby Prescott
 * Fernando Ramsey
 * Mariano Rivera
 * Rubén Rivera
 * Dave Roberts
 * Humberto Robinson
 * Davis Romero
 * Carlos Ruiz
 * Olmedo Sáenz
 * Chico Salmon
 * Manny Sanguillén
 * Pat Scantlebury
 * Fernando Seguignol
 * Rennie Stennett
 * Ray Webster
 * Julio Zuleta