List of adverse effects of pazopanib

This is a list of adverse effects of the anti-cancer drug pazopanib, sorted by frequency of occurrence.

Very common
Very common (>10% incidence) adverse effects include:


 * Reduced appetite
 * Headache
 * Taste changes
 * High blood pressure
 * Diarrhoea
 * Abdominal pain
 * Nausea
 * Vomiting
 * Hair colour change
 * Hand-foot syndrome
 * Hair loss
 * Rash
 * Fatigue
 * Increased alanine aminotransferase
 * Increased aspartate aminotransferase
 * Tumour pain‡
 * Myelosuppression‡
 * Stomatitis‡
 * Exfoliative rash‡
 * Skin hyperpigmentation‡
 * Weight loss‡

Common
Common (1–10% incidence) adverse effects include:


 * Tumour pain†
 * Myelosuppression†
 * Underactive thyroid
 * Dehydration
 * Low level of phosphate in the blood
 * Dizziness
 * Lethargy
 * Paraesthesia
 * Peripheral sensory neuropathy
 * Blurred vision
 * Hot flush
 * Venous thromboembolic event
 * Flushing
 * Nose bleed
 * Voice anomalies
 * Shortness of breath
 * Coughing up blood
 * Stomatitis
 * Indigestion
 * Flatulence
 * Abdominal distension
 * Dry mouth
 * Mouth ulceration
 * Hyperbilirubinaemia
 * Abnormal liver function
 * Hepatotoxicity
 * Skin hypopigmentation
 * Dry skin
 * Itchiness
 * Erythema
 * Skin depigmentation
 * Hyperhidrosis
 * Joint pain
 * Muscle aches
 * Muscle spasms
 * Protein in the urine
 * Mucosal inflammation
 * Weakness
 * Oedema
 * Chest pain
 * Weight loss†
 * Increased blood creatinine
 * Lipase increased
 * Decreased white blood cell count
 * Blood TSH decreased
 * Amylase increased
 * Gamma-glutamyltransferase increased
 * Increased blood pressure
 * Increased blood urea
 * Abnormal liver function test
 * Gingival infection‡
 * Dizziness
 * Insomnia
 * Peripheral sensory neuropathy
 * Heart dysfunction
 * Blurred vision
 * Low heart rate
 * Left ventricular dysfunction
 * Bleeding (including haemorrhage)
 * High blood sugar
 * Low blood sugar

Uncommon
Uncommon (0.1–1% incidence) adverse effects include:


 * Torsades de pointes
 * Heart failure
 * Liver failure
 * GI perforation (may be fatal)
 * Fistula formation

Rare
Rare (<0.1% incidence) adverse effects include:
 * Reversible posterior leucoencephalopathy syndrome