List of clinical studies of menopausal hormone therapy

The following is a list of notable clinical studies of menopausal hormone therapy (estrogen and/or progestogen therapy) in women, including randomized controlled trials and observational studies.

Randomized controlled trials

 * Clinical Study on Hormone Dose Optimisation in Climacteric Symptoms Evaluation (CHOICE)
 * Comparative Effect on Bone Density, Endometrium, and Lipids of Continuous Hormones as Replacement Therapy (CHART)
 * Danish Osteoporosis Prevention Study (DOPS) (open-label)
 * Early versus Late Intervention Trial with Estradiol (ELITE)
 * Estrogen in Prevention of Atherosclerosis Trial (EPAT)
 * Estrogen Replacement and Atherosclerosis (ERA)
 * Estrogen in Venous Thromboembolism Trial (EVTET)
 * Heart and Estrogen/Progestin Replacement Study (HERS)
 * Hormone replacement therapy After Breast cancer — Is iT Safe? (HABITS)
 * Kronos Early Estrogen Prevention Study (KEEPS)
 * Papworth HRT Atherosclerosis Study (PHASE)
 * Perimenopausal Estrogen Replacement Therapy Study (PERT)
 * Postmenopausal Estrogen/Progestin Interventions (PEPI)
 * Stockholm Trial or Stockholm Randomized Trial
 * Women's Estrogen for Stroke Trial (WEST)
 * Women's Estrogen Lipid-Lowering Hormone Atherosclerosis Regression Trial (WELL-HART)
 * Women's Health Initiative Estrogen Study (WHI-E)
 * Women's Health Initiative Estrogen + Progestin Study (WHI-EP)
 * Women's Health, Osteoporosis, Progestin, Estrogen (Women's HOPE)
 * Women's International Study of Long-Duration Oestrogen After Menopause (WISDOM)

Observational studies

 * CECILE (French study)
 * Combined Cohorts of Menopausal Women, studies of Register Based Health Outcomes in Relation to Hormonal Drugs (COMPREHEND)
 * Estrogen and Thromboembolism Risk (ESTHER)
 * European Prospective Investigation into Cancer and Nutrition (EPIC)
 * French cohort: Etude Epidémiologique auprès de femmes de l'Education National (E3N, E3N-EPIC)
 * Framingham Heart Study (FHS)
 * Menopause, Estrogen and Venous Events (MEVE)
 * Menopause: Risk of Breast Cancer, Morbidity and Prevalence (MISSION)
 * Million Women Study (MWS)
 * Nurses' Health Study (NHS)
 * Study of NorpregnAnes on Coagulation (SNAC)
 * Women's Health Initiative Observational Study (WHI-OS)