List of longest-running American first-run syndicated television series

This is a list of the longest running U.S. first-run syndicated television series, ordered by number of broadcast seasons.

To qualify for this list, the programming must originate in North America, shown nationally in the United States, and be first-run syndicated (as opposed to previously aired material, repackaging of previously aired material, or material released in other media). For the purposes of this list, series that were available only on a local or regional basis will be excluded. For series that were presented on U.S. broadcast networks or cable networks at other points in their runs, only the amount aired nationally as original first-run syndicated programming is represented here.

Several long-lasting series were both in first-run syndication and on U.S. network television. For those that were in syndication for fewer than ten seasons, see List of longest-running United States television series.