Lysine 6-dehydrogenase

Lysine 6-dehydrogenase (, L-lysine epsilon-dehydrogenase, L-lysine 6-dehydrogenase, LysDH) is an enzyme with systematic name L-lysine:NAD+ 6-oxidoreductase (deaminating). This enzyme catalyses the following chemical reaction


 * L-lysine + NAD+ $$\rightleftharpoons$$ (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NADH + H+ + NH3 (overall reaction)
 * (1a) L-lysine + NAD+ + H2O $$\rightleftharpoons$$ (S)-2-amino-6-oxohexanoate + NADH + H+ + NH3
 * (1b) (S)-2-amino-6-oxohexanoate $$\rightleftharpoons$$ (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O (spontaneous)

The enzyme is highly specific for L-lysine as substrate, although S-(2-aminoethyl)-L-cysteine can act as a substrate, but more slowly.