MOTS-c

MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a peptide encoded in mitochondrial DNA. It is believed to be involved in skeletal muscle and glucose metabolism. It is upregulated in response to exercise, and is considered an exercise mimetic.

MOTS-c binds to casein kinase 2.

Society and culture
Researchers discovered MOTS-c in 2015.

MOTS-c is not approved to treat any medical condition and is banned by the World Anti-Doping Agency, explicitly beginning in 2024.