Membrane-type matrix metalloproteinase-1

Membrane-type matrix metalloproteinase-1 (, matrix metalloproteinase 14) is an enzyme. This enzyme catalyses the following chemical reaction


 * Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37-Leu. Other bonds hydrolysed include Gly35-Ile in the propeptide of collagenase 3, and Asn341-Phe, Asp441-Leu and Gln354-Thr in the aggrecan interglobular domain

This enzyme belongs to peptidase family M10.