Mipafox

Mipafox is a highly toxic organophosphate insecticide that is an irreversible acetylcholinesterase inhibitor and is resistant to cholinesterase reactivators. It was developed in the 1950s and is now believed to be no longer in use.

Toxicity
There are case reports of delayed neurotoxicity and paralysis due to acute exposure to mipafox.

Synthesis
Phosphoryl chloride is first reacted with isopropylamine. The resulting product is then reacted with potassium fluoride or ammonium fluoride to produce mipafox.