Mycosubtilin

Mycosubtilin is a natural lipopeptide with antifungal and hemolytic activities and isolated from Bacillus species. It belongs to the iturin lipopeptide family.

Definition
Mycosubtilin is a natural lipopeptide. It is produced by the strains of Bacillus spp mainly by Bacillus subtilis. It was discovered due to its antifungal activities. It belongs to the family of iturin lipopeptides

Structure
Mycosubtilin is a heptapeptide, cyclized in a ring with a β-amino fatty acid. The peptide sequence is composed of L -Asn- D -Tyr- D -Asn- L -Gln- L -Pro- D -Ser- L -Asn.

Biological activities
Mycosubtilin has strong antifungal and hemolytic activities. It is active against fungi and yeasts such as Candida albicans, Candida tropicalis, Saccharomyces cerevisiae, Penicillium notatum, and Fusarium oxysporum.

Its antibacterial activity is quite limited to bacteria such as Micrococcus luteus.