Ozagrel

Ozagrel (INN) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.

Synthesis

 * Ozagrel synthesis.svg

The free-radical halogenation of ethyl 4-methylcinnamate (1) with N-bromosuccinimide in the presence of benzoyl peroxide gives ethyl 4-bromomethylcinnamate (2). Alkylation of imidazole (3) with this material gives the ethyl ester (4) of the drug, which is saponified to give ozagrel.