Ozzy & Drix

Ozzy & Drix is an American animated television series based on the 2001 film Osmosis Jones. It centers on Osmosis "Ozzy" Jones, a cheeky-chappy white blood cell, and Drix, a level-headed cold pill, who battle germs and viruses inside the body of teenage boy Hector Cruz. The series is set in a stylized version of the human body, which resembles a city where microorganisms and cells are anthropomorphic.

Produced by Conundrum Entertainment and Warner Bros. Animation, the series aired on Kids' WB for two seasons and 26 episodes from 2002 to 2004. It also aired on Cartoon Network from 2003 to 2006.

Premise
At the beginning of the series, Osmosis "Ozzy" Jones (voiced by Phil LaMarr impersonating Chris Rock from the film), a white blood cell with an impulsive personality and a penchant for challenging authority, and Drix (voiced by Jeff Bennett impersonating David Hyde Pierce in the same film), a straight-laced and by-the-books cold pill, pursue a scarlet fever bacterium (voiced by Tim Curry). During the chase, the three get sucked up by a mosquito from their host body Frank DeTorre (voiced by Jeff Bennett) and are transported to the body of a teenage boy named Hector Cruz (voiced by Justin Cowden). After defeating the bacterium and settling into their new home, Ozzy and Drix are hired as private investigators, vowing to protect Hector's health and guide him through the misadventures of adolescence.

Supporting characters include Maria Amino (voiced by Tasia Valenza), a white blood cell cop who is highly skilled at fighting and also becomes a love interest for Drix; Mayor Paul Spryman (voiced by Alanna Ubach), the immature teenage mayor of the city of Hector; Chief Gluteus (voiced by Jim Cummings), a stern muscle cell who serves as the city's police chief and Maria's superior; Ellen Patella (voiced by Vivica A. Fox), an attorney at law who helps cells find homes in Hector, and who becomes Ozzy's new love interest to replace Leah Estrogen after forever leaving her and Frank; and the Brain Cell Advisors (voiced by Pat Fraley), advisors who help Mayor Spryman run the city due to Spryman being incompetent in his job.

Recurring characters include The Mole (voiced by Jeffrey Tambor), a former secret agent who holds information on what is happening within Hector; Dander (vocal effects provided by Frank Welker), Drix's pet dog germ formed from the saliva of Hector's dog Uno; Christine Kolchuck (voiced by Kimberly Brooks), a friendly student who Hector has a crush on and looks out for Hector; Travis Lum (voiced by Rob Paulsen), Hector's classmate and best friend who also looks out for him; Ernst Strepfinger (voiced by Brad Garrett in season 1, Jim Cummings in season 2), a villainous germ who uses a gang of germs and viruses to carry out his dirty work; Uno (vocal effects provided by Frank Welker), Hector's dog whom he adopted in "Oh, My Dog"; and Hector's supportive parents, Mr. and Mrs. Cruz (voiced by Alanna Ubach and Joe Lala) who look after Hector's well-being.

Production
Unlike the original film it was spun-off from, Ozzy & Drix was entirely animated and contained no live-action scenes while being considered in its own continuity as this version of Frank DeTorre is still in bad shape. The series was also less intense and contained little adult humor compared to the film. The voices of Ozzy and Drix were recast with LaMarr replacing Chris Rock as Ozzy and Bennett replacing David Hyde Pierce as Drix. In multiple episodes, producer Ron Myrick integrated stock footage from the original film such as the human body's traffic, the inside of the mouth, and the dam bursting in the runny nose.

Ozzy and Drix (not counting this show's version of Frank as he only appears in the first episode and made a small cameo in the ninth episode) are only two of the characters to return. Ozzy's girlfriend Leah, along with ex-mayor Phlegmming, current mayor Tom Colonic, Mrs. Boyd, Frank's daughter Shane, and Frank's brother Bob do not appear nor mentioned in the series.

Home media
The complete series was released on DVD on June 20, 2017, as manufactured on demand (MOD) on DVD-R and part of the Warner Archive Collection.