PISRT1

PISRT1 (polled intersex syndrome regulated transcript 1) is a long non-coding RNA. It was originally thought to be implicated in the polled intersex (PIS) mutation in goats, but this has been shown to not be the case. It has also been shown not to be involved in sex determination in the rodent Ellobius lutescens and in dogs, and is unlikely to be involved in sex-specific gonad differentiation in mice.

Polled Intersex Syndrome (PIS) is a disorder of sexual development seen in goats. The disorder shows an association with the polled phenotype and intersexuality. XX goats present with testes and are SRY negative. Studies have shown that PIS is caused by a deletion of a 10.1-kb DNA element which regulates the transcription of both PISRT1 and FOXL2, with the latter having been shown to be responsible for sex-determination in goats.