Piketoprofen

Piketoprofen (INN; trade names Calmatel, Picalm) is a nonsteroidal anti-inflammatory drug (NSAID) for topical use in form of a cream.

Chemically, it is the 4-picolineamide of the NSAID ketoprofen.

Synthesis

 * Piketoprofen synthesis.svg

Thionyl chloride reacts with ketoprofen to form its acid chloride (2). Amide formation with 2-amino-4-methylpyridine (3) gives piketoprofen.