Polypeptide N-acetylgalactosaminyltransferase

In enzymology, a polypeptide N-acetylgalactosaminyltransferase is an enzyme that catalyzes the chemical reaction


 * UDP-N-acetyl-D-galactosamine + polypeptide $$\rightleftharpoons$$ UDP + N-acetyl-D-galactosaminyl-polypeptide

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-galactosamine and polypeptide, whereas its two products are UDP and N-acetyl-D-galactosaminyl-polypeptide.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. This enzyme participates in o-glycan biosynthesis and glycan structures - biosynthesis 1. It has 2 cofactors: manganese, and calcium.

Nomenclature
The systematic name of this enzyme class is UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase. Other names in common use include:


 * protein-UDP acetylgalactosaminyltransferase,
 * UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase,
 * UDP-N-acetylgalactosamine:kappa-casein polypeptide,
 * N-acetylgalactosaminyltransferase,
 * uridine diphosphoacetylgalactosamine-glycoprotein,
 * acetylgalactosaminyltransferase,
 * glycoprotein acetylgalactosaminyltransferase,
 * polypeptide-N-acetylgalactosamine transferase,
 * UDP-acetylgalactosamine-glycoprotein,
 * acetylgalactosaminyltransferase,
 * UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase,
 * UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase,
 * UDP-N-acetyl-alpha-D-galactosamine:polypeptide,
 * N-acetylgalactosaminyltransferase,
 * UDP-N-acetylgalactosamine-glycoprotein,
 * N-acetylgalactosaminyltransferase,
 * UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase,
 * UDP-N-acetylgalactosamine:polypeptide,
 * N-acetylgalactosaminyltransferase, and
 * UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase.