Porton Down

Porton Down is a science and defence technology campus in Wiltshire, England, just north-east of the village of Porton, near Salisbury. It is home to two British government facilities: a site of the Ministry of Defence's Defence Science and Technology Laboratory – known for over 100 years as one of the UK's most secretive and controversial military research facilities, occupying 7000 acre – and a site of the UK Health Security Agency. Since 2018, part of the campus has housed Porton Science Park, which is owned and operated by Wiltshire Council and has private sector companies in the health, life science and defence and security sectors.

Location
Porton Down is just north-east of the village of Porton, near Salisbury, in Wiltshire, England. To the north-west lies the MoD Boscombe Down airfield operated by Qinetiq. On some maps, the land surrounding the complex is identified as a "Danger Area".

History of government use
Porton Down opened in 1916 as the War Department Experimental Station, shortly thereafter renamed the Royal Engineers Experimental Station, for testing chemical weapons in response to German use of this means of war in 1915. The laboratory's remit was to conduct research and development regarding chemical weapons agents used by the British armed forces in the First World War, such as chlorine, mustard gas, and phosgene.

Work at Porton started in March 1916. At the time, only a few cottages and farm buildings were scattered on the downs at Porton and Idmiston. By May 1917, the focus for anti-gas defence and respirator development had moved from London to Porton Down, and by 1918, the original two huts had become a large hutted camp with 50 officers and 1,100 other ranks. After the Armistice in 1918, Porton Down was reduced to a skeleton staff.

Post First World War
In 1919, the War Office set up the Holland Committee to consider the future of chemical warfare and defence. By 1920, the Cabinet agreed to the committee's recommendation that work would continue at Porton Down. From that date a slow permanent building programme began, coupled with the gradual recruitment of civilian scientists. By 1922, there were 380 servicemen, 23 scientific and technical civil servants, and 25 "civilian subordinates". In 1923 the newly formed Silver Star Motor Services started a bus service to link Salisbury and Porton Down. By 1925, the civilian staff had doubled.

By 1926, the chemical defence aspects of Air Raid Precautions (ARP) for the civilian population was added to the Station's responsibilities. In 1929 the Royal Engineers Experimental Station became the Chemical Warfare Experimental Station (CWES) (1929–1930), and in 1930 the Chemical Defence Experimental Station (CDES) (1930–1948). In 1930, Britain ratified the 1925 Geneva Protocol with reservations, which permitted the use of chemical warfare agents only in retaliation. By 1938, the international situation was such that the Cabinet authorised offensive chemical warfare research and development and the production of war reserve stocks of chemical warfare agents by the chemical industry. This included conducting chemical warfare trials, known as the Rawalpindi experiments, on servicemen in the British Indian Army to test the effects of mustard gas.

Second World War
During the Second World War, research at CDES concentrated on chemical weapons such as nitrogen mustard. As Allied armies penetrated Germany, they discovered operational stockpiles of munitions and weapons that contained new chemical warfare agents, including highly toxic organophosphorous nerve agents such as sarin, unknown to Britain and the Allies at the time.

To examine biological weapons, a highly secret separate department, called the Biology Department, Porton (BDP), was established within CDES in 1940, under veteran microbiologist Paul Fildes. Its focus included anthrax and botulinum toxin, and in 1942 it infamously carried out tests of an anthrax bio-weapon at Gruinard Island. In 1946, it was renamed the Microbiological Research Department (MRD) and, in 1957, the Microbiological Research Establishment (MRE).

The Common Cold Unit (CCU) was sometimes confused with the MRE, with which it occasionally collaborated but was not officially connected. The CCU was at Harvard Hospital, Harnham Down, on the west side of Salisbury.

Post-war period
When the Second World War ended, the advanced state of German technology regarding organophosphorus nerve agents such as tabun, sarin and soman, had surprised the Allies, who were eager to capitalise on it. Subsequent research took the newly discovered German nerve agents as a starting point, and eventually VX nerve agent was developed at Porton Down in 1952.

In the late 1940s and early 1950s, research and development at Porton Down was aimed at providing Britain with the means to arm itself with a modern nerve agent-based capability and to develop specific means of defence against these agents. In the end these aims came to nothing on the offensive side because of the decision to abandon any sort of British chemical warfare capability in favour of nuclear weapons. On the defensive side there were years of difficult work to develop the means of prophylaxis, therapy, rapid detection and identification, decontamination, and more effective protection of the body against nerve agents, capable of exerting effects through the skin, the eyes and respiratory tract.

Tests were carried out on servicemen to determine the effects of nerve agents on human subjects, with one recorded death due to a nerve gas experiment. There have been persistent allegations of unethical human experimentation at Porton Down, such as those relating to the death of Leading Aircraftman Ronald Maddison, aged 20, in 1953. Maddison was taking part in sarin nerve agent toxicity tests; sarin was dripped onto his arm and he died shortly afterwards.

In the 1950s, the station, now renamed the Chemical Defence Experimental Establishment (CDEE), became involved with the development of CS, a riot-control agent, and took an increasing role in trauma and wound ballistics work. Both these facets of Porton Down's work had become more important because of the unrest and increasing violence in Northern Ireland.

On 1 August 1962, Geoffrey Bacon, a scientist at the Microbiological Research Establishment, died from an accidental infection of the plague bacterium Yersinia pestis. In the same month an autoclave exploded, shattering two windows. Both incidents generated considerable media coverage at the time.

In 1970, the senior establishment at Porton Down was renamed the Chemical Defence Establishment (CDE) for the next 21 years. Preoccupation with defence against nerve agents continued, but in the 1970s and 1980s, the Establishment was also concerned with studying reported chemical warfare by Iraq against Iran and against its own Kurdish population.

Porton Down was the laboratory where initial samples of the Ebola virus were sent in 1976 during the first confirmed outbreak of the disease in Africa. The laboratory now contains samples of some of the world's most aggressive pathogens, including Ebola, anthrax and the plague, and is leading the UK's current research into viral inoculations.

21st century
Until 2001, the military installations based at Porton Down were part of the UK government's Defence Evaluation and Research Agency (DERA). DERA was to be split into two parts: QinetiQ, initially a government-owned company; and, the Defence Science and Technology Laboratory (Dstl), created to incorporate the activities of DERA deemed unsuitable for the privatisation planned for QinetiQ; particularly the Porton Down site.

In 2013, Dstl scientists tested samples from Syria for sarin, which is still manufactured there, to assess soldiers' equipment.

In April 2018, Porton Down was responsible for analysis of the substance used in the nearby Salisbury poisonings, which was ultimately identified by Dstl as a Novichok nerve agent.

Site names
The location's government use has been split into two separately controlled locations since 1979: the original military establishment under the Ministry of Defence, and the site to the south under the Department of Health, which had been opened in 1951 for the Microbiological Research Establishment, then in 1979 transferred to the Ministry of Health to focus on public health research, with the Defence aspects returning to the then-titled Chemical Defence Establishment.

Sutton Oak, Merseyside
A factory in Sutton Oak, St Helens was requisitioned in 1917 by the War Department, renamed HM Factory, Sutton Oak and started producing the chemical warfare agent diphenyl chloroarsine. The site switched to producing Adamsite in 1922. In 1923 the War Office halted the requisition and purchased the site, renaming it the War Office Research Establishment, a.k.a. Chemical Warfare Research Establishment, and later the Chemical Defence Research Establishment Sutton Oak. During the 1920s, the site switched to producing mustard gas products, starting with the HS variant and adding the HT variant in the 1930s, and also filling armaments. After WW2, the site also produced the nerve agent sarin for experimental purposes. The site closed in 1957, with much of the work transferring to Chemical Defence Establishment Nancekuke.

RRH Portreath, Cornwall
This Royal Air Force site, built in 1940, was renamed Chemical Defence Establishment Nancekuke in July 1949. Manufacture of sarin in a pilot production facility commenced there in the early 1950s, producing about 20 tons from 1954 until 1956. It was intended as a stockpile and production facility for the UK's chemical defences during the Cold War, focussed on nerve agents, including small amounts of VX intended mainly for laboratory test purposes and to validate plant designs and optimise chemical processes for potential mass-production; full-scale production of VX agent never took place. In the late 1950s, the chemical weapons production plant was mothballed, but was maintained through the 1960s and 1970s in a state whereby production could easily re-commence if required.

Non-government use
A few small scientific start-ups were allowed to use buildings on the Porton Down campus from the mid-1990s. Tetricus Science Park has housed companies including and GW Pharmaceuticals.

In 2014, an expansion plan was predicted to create 2,000 jobs. Creation of Porton Science Park started in 2016, with £9.5m in funding from Wiltshire Council, the Swindon and Wiltshire Local Enterprise Partnership and the European Regional Development Fund. The first building opened in 2018, with Ploughshare Innovations, Dstl's technology transfer company, among the tenants. Further expansion began in 2022.

Open air
In 1942, Gruinard Island was dangerously contaminated with anthrax after a cloud of anthrax spores was released over the island during a trial. In 1981, a team of activists landed on the island and collected soil samples, a bag of which was left at the door at Porton Down. Testing showed that it still contained anthrax spores and in 1986 the Government felt obliged to take necessary steps to successfully decontaminate the island.

Between 1963 and 1975 the MRE carried out trials in Lyme Bay in which live bacteria were sprayed from a ship to be carried ashore by the wind to simulate an anthrax attack. The bacteria sprayed were Bacillus globigii and Escherichia coli; these were originally considered to be less dangerous than other bacterial strains, but it was later admitted that the bacteria could adversely affect some vulnerable people. The town of Weymouth lay downwind of the spraying. When the trials became public knowledge in the late 1990s, Dorset County Council, Weymouth and Portland Borough Council and Purbeck District Council demanded a public inquiry to investigate the experiments. The Government refused a Public Inquiry but instead commissioned Professor Brian Spratt, to conduct an Independent Review of the possible adverse health effects. He concluded that individuals with certain chronic conditions may have been affected.

In 1954 the British Government sent biological warfare scientists to the Bahamas to release Venezuelan equine encephalitis viruses near an uninhabited island.

Other research showed that, in the Obanaghoro region of southern Nigeria, four British scientific missions dispersed, and assessed the effect of, experimental nerve gases over a fifteen-month period. Historians were unable to determine who did the extremely hazardous work of "hand-charging" weapons containing the nerve agents, while the effects on the local population and the extent of soil contamination are also unknown.

Human trials
Porton Down has been involved in human testing at various points throughout the Ministry of Defence's use of the site. Up to 20,000 people took part in various trials from 1949 up to 1989: From 1999 until 2006, it was investigated under Operation Antler. In 2002 a first inquest and in May 2004, a second inquest into the death of Ronald Maddison during testing of the nerve agent sarin commenced after his relatives and their supporters had lobbied for many years, which found his death to have been unlawful. The Ministry of Defence challenged the verdict which was upheld and the government settled the case in 2006. In 2006, 500 veterans claimed they suffered from the experiments.

In February 2006, three ex-servicemen were awarded compensation in an out-of-court settlement after they had claimed they were given LSD without their consent during the 1950s. In 2008, the MoD paid 360 veterans of the tests £3m without admitting liability.

Secrecy
Most of the work carried out at Porton Down has to date remained secret. Bruce George, Member of Parliament and Chairman of the Defence Select Committee, told BBC News on 20 August 1999 that: "I would not say that the Defence Committee is micro-managing either DERA or Porton Down. We visit it, but, with eleven members of Parliament and five staff covering a labyrinthine department like the Ministry of Defence and the Armed Forces, it would be quite erroneous of me and misleading for me to say that we know everything that's going on in Porton Down. It's too big for us to know, and secondly, there are many things happening there that I'm not even certain Ministers are fully aware of, let alone Parliamentarians."

Use of animals
Dstl's Porton Down site conducts animal testing. The "three Rs" of "reduce" (the number of animals used), "refine" (animal procedures) and "replace" (animal tests with non-animal tests) are used as the basic code of practice. There has been a decrease in animal experimentation in recent years. Dstl complies with all UK legislation relating to animals. Animals used include mice, guinea pigs, rats, pigs, ferrets, sheep, and non-human primates (believed to be marmosets and rhesus macaque). Publicly released figures are detailed below:

Different departments at Porton Down use animal experiments in different ways. Dstl's Biomedical Sciences department is involved with drug evaluation and efficacy testing (toxicology, pharmacology, physiology, behavioural science, human science), trauma and surgery studies, and animal breeding. The Physical Sciences department also uses animals in its "Armour Physics" research.

Like other aspects of research at Porton Down, precise details of animal experiments are generally kept secret. Media reports have suggested they include exposing monkeys to anthrax, draining the blood of pigs and injecting them with E. coli bacteria, and exposing animals to a variety of lethal, toxic nerve agents. Different animals are used for very different purposes. According to a 2002 report from the Animal Welfare Advisory Committee of the Ministry of Defence, mice are used mainly to research "the development of vaccines and treatments for microbial and viral infections", while pigs are used to "develop personal protective equipment to protect against blast injury to the thorax".

Novels
An institute similar to Porton Down, the Mordon Microbiological Research Establishment, features in the 1962 novel The Satan Bug by Alistair MacLean. Porton Down features in the 1977 novel The Enemy by Desmond Bagley, the 2010 mystery novel Before the Poison by Peter Robinson, and the 2022 novel Tick Tock by Simon Mayo.

Movies
Porton Down is featured in the 2022 psychological horror film The Sleep Experiment directed by John Farrelly. Two detectives begin an investigation into a disastrous secret military experiment where five prisoners were kept awake for thirty days in the facility.

Television
Porton Down and activities there during the 1940s and early 1950s were a significant plot point in Episodes One and Two of the second season of ITV's mystery series The Bletchley Circle. Experiments conducted at Porton Down also appear in the BBC detective drama Spooks, including the development of the VX Nerve Agent and other potentially deadly biological weapons.

Porton Down is referenced frequently in the 2020 BBC TV drama The Salisbury Poisonings, portraying its role in testing substances linked to the 2018 poisoning of Sergei and Yulia Skripal.

Porton Down is referenced frequently in the ITV Trigger Point series, as the origin of a military grade explosive compound HMX-319 which is nicknamed "Her Majesty's Explosive".

Comics
Grimbledon Down was a comic strip by British cartoonist Bill Tidy, published for many years by New Scientist. The strip was set in an ostensibly fictitious UK government research lab, referring to the controversial Porton Down biochemical research facility.

Music
"Porton Down" is the name of a song by Peter Hammill. The song "Jeopardy" by Skyclad is about the experiments developed in Porton Down.