RBX1

RING-box protein 1 is a protein that in humans is encoded by the RBX1 gene.

Function
This gene encodes an evolutionarily conserved protein that interacts with cullins. The protein plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over.

Interactions
RBX1 has been shown to interact with:


 * CAND1,
 * CUL1,
 * CUL2,
 * CUL4A,
 * CUL5
 * CUL7,
 * DCUN1D1, and
 * P70-S6 Kinase 1.