Real Time with Bill Maher season 21

This is a list of episodes from the twenty-first season of Real Time with Bill Maher. The season premiered on January 20, 2023. On February 3, the post-show Overtime segment was added as part of the CNN Tonight programming airing Friday nights at 11:30 pm EST. On May 2, it was announced that production of the show was shut down due to the 2023 Writers Guild of America strike.

On September 13, Maher announced on Twitter his intention to go back on the air, but due to the strike, only unscripted portions of his show were to return. The show was supposed to return on September 22. However, five days later Maher further postponed his show out of respect for the writers' strike. Following an agreement reached between the WGA and the Alliance of Motion Picture and Television Producers, the strike ended on September 27 allowing the show to return two days later on September 29.