Rectum

The rectum (: rectums or recta) is the final straight portion of the large intestine in humans and some other mammals, and the gut in others. The adult human rectum is about 12 cm long, and begins at the rectosigmoid junction (the end of the sigmoid colon) at the level of the third sacral vertebra or the sacral promontory depending upon what definition is used. Its diameter is similar to that of the sigmoid colon at its commencement, but it is dilated near its termination, forming the rectal ampulla. It terminates at the level of the anorectal ring (the level of the puborectalis sling) or the dentate line, again depending upon which definition is used. In humans, the rectum is followed by the anal canal, which is about 4 cm long, before the gastrointestinal tract terminates at the anal verge. The word rectum comes from the Latin rēctum intestīnum, meaning straight intestine.

Structure
The rectum is a part of the lower gastrointestinal tract. The rectum is a continuation of the sigmoid colon, and connects to the anus. The rectum follows the shape of the sacrum and ends in an expanded section called an ampulla where feces is stored before its release via the anal canal. An ampulla is a cavity, or the dilated end of a duct, shaped like a Roman ampulla. The rectum joins with the sigmoid colon at the level of S3, and joins with the anal canal as it passes through the pelvic floor muscles.

Unlike other portions of the colon, the rectum does not have distinct taeniae coli. The taeniae blend with one another in the sigmoid colon five centimeters above the rectum, becoming a singular longitudinal muscle that surrounds the rectum on all sides for its entire length.

Blood supply and drainage
The blood supply of the rectum changes between the top and bottom portions. The top two thirds is supplied by the superior rectal artery. The lower third is supplied by the middle and inferior rectal arteries.

The superior rectal artery is a single artery that is a continuation of the inferior mesenteric artery, when it crosses the pelvic brim. It enters the mesorectum at the level of S3, and then splits into two branches, which run at the lateral back part of the rectum, and then the sides of the rectum. These then end in branches in the submucosa, which join with with branches of the middle and inferior rectal arteries.

Microanatomy
The microanatomy of the wall of the rectum is similar to the rest of the gastrointestinal tract; namely, that it possesses a mucosa with a lining of a single layer of column-shaped cells with mucous-secreting goblet cells interspersed, resting on a lamina propria, with a layer of smooth muscle called muscularis mucosa. This sits on an underlying submucosa of connective tissue, surrounded by a muscularis propria of two bands of muscle, an inner circular band and an outer longitudinal one. There are a higher concentration of goblet cells in the rectal mucosa than other parts of the gastrointestinal tract.

The lining of the rectum changes sharply at the line where the rectum meets the anus. Here, the lining changes from the column-shaped cells of the rectum to multiple layers of flat cells.

Function
The rectum acts as a temporary storage site for feces. The rectum receives fecal material from the descending colon, transmitted through regular muscle contractions called peristalsis. As the rectal walls expand due to the materials filling it from within, stretch receptors from the nervous system located in the rectal walls stimulate the desire to pass feces, a process called defecation.

An internal and external anal sphincter, and resting contraction of the puborectalis, prevent leakage of feces (fecal incontinence). As the rectum becomes more distended, the sphincters relax and a reflex expulsion of the contents of the rectum occurs. Expulsion occurs through contractions of the muscles of the rectum.

The urge to voluntarily defecate occurs after the rectal pressure increases to beyond 18 mmHg; and reflex expulsion at 55 mmHg. In voluntary defecation, in addition to contraction of the rectal muscles and relaxation of the external anal sphincter, abdominal muscle contraction, and relaxation of the puborectalis muscle occurs. This acts to make the angle between the rectum and anus straighter, and facilitate defecation.

Examination
For the diagnosis of certain ailments, a rectal exam may be done. These include faecal impaction, prostatic cancer and benign prostatic hypertrophy in men, faecal incontinence, and internal haemorrhoids. Forms of medical imaging used to examine the rectum include CT scans and MRI scans. An ultrasound probe may be inserted into the rectum to view nearby structures such as the prostate.

Colonoscopy and sigmoidoscopy are forms of endoscopy that use a guided camera to directly view the rectum. The instruments may have the ability to take biopsies if needed, for diagnosis of diseases such as cancer. A proctoscope is another instrument that is used to visualise the rectum.

Body temperature can also be taken in the rectum. Rectal temperature can be taken by inserting a medical thermometer not more than 25 mm into the rectum via the anus. A mercury thermometer should be inserted for 3 to 5 minutes; a digital thermometer should remain inserted until it beeps. Normal rectal temperature generally ranges from 36 to 38 C and is about 0.5 °C above oral (mouth) temperature and about 1 °C above axilla (armpit) temperature. Availability of less invasive temperature-taking methods including tympanic (ear) and forehead thermometers has facilitated reduced use of this method.

Route of administration
Some medications are also administered via the rectum (per rectum). By their definitions, suppositories are inserted, and enemas are injected into the rectum. Medications might be given via the rectum to relieve constipation, to treat conditions near the rectum, such as fissures or haemorrhoids, or to give medications that are systemically active when taking them by mouth is not possible. People do not tend to like medications administered by this route because of both cultural issues, discomfort, and issues that may affect the medication working, such as leakage.

Constipation
One cause of constipation is faecal impaction in the rectum, in which a dry, hard stool forms. Constipation is most commonly due to dietary and lifestyle factors such as inadequate hydration, immobility, and lack of dietary fibre, although there are many potential causes. Such causes may include obstruction because of narrowing, local disease (such as Crohn's disease, fissures or haemorrhoids), or diseases affecting the neurological control of the bowel, or slow bowel transit time, including spinal cord injury and multiple sclerosis; use of medications such as opioids, and conditions such as diabetes mellitus, as well as severe illness. High calcium levels and low thyroid activity may also cause constipation.

Testing may be carried out to investigate the cause. This may include blood tests such as biochemistry, calcium levels, thyroid function tests. A digital rectal examination may be performed to see if there is stool in the rectum, and whether there is an obstruction. When symptoms such as weight loss, bleeding through the rectum, or pain are present, additional investigations such as a CT scan may be ordered. If constipation persists despite simple treatments, testing may also include anal manometry to measure pressures in the anus and rectum, electrophysiological studies, and magnetic resonance proctography.

In general however, constipation is treated by improving factors such as hydration, exercise, and dietary fibre. Laxatives may be used. Constipation that persists may require enemas or suppositories. Sometimes, use of the fingers or hand (manual evacuation) is required. Although peristalsis in the colon delivers material to the rectum, laxatives such as bisacodyl or senna that induce peristalsis in the large bowel do not appear to initiate peristalsis in the rectum. They induce a sensation of rectal fullness and contraction that frequently leads to defecation, but without the distinct waves of activity characteristic of peristalsis.

Inflammation

 * Proctitis is inflammation of the anus and the rectum.
 * Ulcerative colitis, one form of inflammatory bowel disease that causes ulcers that affect the rectum. This may be episodic, over a person's lifetime. These may cause blood to be visible in the stool., the cause is unknown.

Cancer

 * Rectal cancer, a subgroup of colorectal cancer specific to the rectum.

Other diseases
Other diseases of the rectum include:


 * Rectal prolapse, referring to the prolapse of the rectum into the anus or external area. This is commonly caused by a weakened pelvic floor after childbirth
 * In the context of mesenteric ischemia, the upper rectum is sometimes referred to as Sudeck's point and is of clinical importance as a watershed region between the inferior mesenteric artery circulation and the internal iliac artery circulation via the middle rectal artery and thus prone to ischemia. Sudeck's point is often referred to along with Griffith's point at the splenic flexure as a watershed region.

Sexual stimulation
Due to the proximity of the anterior wall of the rectum to the vagina in females or to the prostate in males, and the shared nerves thereof, rectal stimulation or penetration can result in sexual arousal.

Etymology
English rectum is derived from the Latin intestinum rectum 'straight gut', a calque  of Ancient Greek ἀπευθυσμένον ἔντερον, derived from ἀπευθύνειν, to make straight, and ἔντερον, gut, attested in the writings of Greek physician Galen. During his anatomic investigations on animal corpses, Galen observed the rectum to be straight instead of curved as in humans. The expressions ἀπευθυσμένον ἔντερον and intestinum rectum are therefore not appropriate descriptions of the rectum in humans. Apeuthysmenon is the Latinization of ἀπευθυσμένον and euthyenteron has a similar meaning  (εὐθύς 'straight ). Much of the knowledge of the anatomy of the rectum comes from detailed descriptions provided by Andreas Vesalius in 1543.