Route 666

Route 666 may refer to:

Canada

 * Alberta Highway 666
 * Ontario Highway 666, renumbered to 658 in 1985

Ireland

 * R666 road (Ireland)

United Kingdom

 * A666 road

United States

 * U.S. Route 666, renumbered in 2003 to U.S. Route 491
 * Florida State Road 666
 * County Route 666 (Atlantic County, New Jersey)
 * Ohio State Route 666
 * Pennsylvania Route 666

Comics

 * Route 666 (comics), a 2002 comic book published by CrossGen Comics

Music

 * Route 666 (Helltrain album), 2006
 * Route 666 (The Iron Maidens album), 2007
 * Route 666 (The Hamsters album), 1995
 * "Route 666", a song by God Is an Astronaut from The End of the Beginning
 * "Route 666", a song by The Comsat Angels from My Mind's Eye
 * "Route 666", a song by BB Tone from Natural Born Killers
 * "Hwy 666", a song by Corey Taylor from the 2022 album CMFT

Film and television

 * Route 666 (film), a 2001 American horror film
 * Route 666: America's Scariest Home Haunts, an Internet TV series
 * "Route 666" (Married... with Children), an episode of Married... with Children
 * "Route 666" (Supernatural), an episode of Supernatural
 * "Route 666", a fictional funhouse ride in the 2004 film The Machinist

Video games

 * Ride to Hell: Route 666, a cancelled digitally distributed spinoff of Ride to Hell: Retribution