SGTA

Small glutamine-rich tetratricopeptide repeat-containing protein alpha is a protein that in humans is encoded by the SGTA gene. SGTA orthologs have also been identified in several mammals for which complete genome data are available. STGA belongs to a family of co-chaperone proteins that obtain a TPR motif. STGA was discovered just 15 years ago.

Function
The molecular function of the protein states that SGTA is a small glutamine-rich tetratricopeptide repeat (TRP)-containing protein, ubiquitously expressed, interacting with the NS1 protein of parvovirus H-1.

The SGTA gene encodes a protein that is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.

Overview of main functions:


 * hormone signaling
 * viral assembly and release
 * cell cycle and apoptosis
 * intracellular compartmentalization
 * neuronal synaptic transmission
 * post-translational transport and modification of proteins.

Small glutamine-rich tetratricopeptide repeat-containing protein alpha (STGA) acts as a co-chaperone and regulator of androgen and growth hormone receptor signaling. The protein also mediates targets to the endoplasmic reticulum

Interactions
SGTA has been shown to interact with Growth hormone receptor.

Interacting Proteins for the SGTA Gene:


 * HSPA4
 * BAG6
 * UBL4A
 * HSPA8
 * GET4

Associated Diseases

 * Prostate, ovary, liver, and esophagus cancer
 * Hormone-related polycystic ovary syndrome
 * Amyloid-related Alzheimer's
 * Prion Diseases