San Leone

San Leone may refer to various places, jurisdictions and people:


 * Saint Leo (disambiguation)
 * Saint-Léon (disambiguation)
 * San Leone (see), a former bishopric in Calabria (Italy), nominally restored as Catholic titular see
 * a suburb of the modern Agrigento on Sicily (Italy)
 * San Leone (river), a river in the Province of the river Agrigento, Sicily, Italy