Sialic acid binding ig-like lectin 15

Sialic acid binding Ig-like lectin 15 (Siglec-15) is a protein that in humans is encoded by the SIGLEC15 gene. Siglec-15 is predominately expressed on osteoclasts, elevated levels of Siglec- 15 in the bone metastatic niche can promote tumor-induced osteoclastogenesis as well as suppress antigen-specific T cell responses. Researchers demonstrated that antibody blockade of the Siglec-15/sialic acid glycol-immune checkpoint axis can act as a potential treatment for breast cancer bone metastasis.