Small nucleolar RNA psi18S-1377

In molecular biology, Small nucleolar RNA psi18S-1377 (also known as snoRNA psi28S-1377) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.

This Drosophila-specific snoRNA is a member of the H/ACA box class of snoRNA and is predicted to be responsible for guiding the modification of uridines 1377 and 1279 to pseudouridine in Drosophila 18S rRNA.