TTC37

TTC37 (Tetratricopeptide repeat domain 37) is a protein which in humans is encoded by gene TTC37, located on chromosome 5.

Structure
The length of the polypeptide chain is 1,564 amino acids, and the molecular weight is 175,486 Da. TTC37 contains six tetratricopeptide repeat domains.

Function
TTC37 is a component of the Ski complex which is involved in exosome mediated RNA decay.

Subcellular distribution
It is localized in the cytoplasmatic space and the cell nucleus.

Clinical significance
Mutation in the TTC37 gene are associated with tricho-hepato-enteric syndrome.