Talk:2-Oxazolidone

How do they kill bacteria
Can we have something on how they disrupt protein synthesis ? Rod57 (talk) 03:01, 6 December 2009 (UTC)


 * Linezolid says it binds to the 50S ribosomal subunit. (Is that specific to bacteria ?) - Rod57 (talk) 22:02, 14 January 2013 (UTC)


 * Yes, it is specific to bacteria. Aglo123 (talk) 15:34, 11 February 2017 (UTC)

oxazolidinones
Can we say 2-oxazolidone is a contraction of oxazolidine-2-one, oxazolidinone is a contraction of oxazolidine-dione? The fungicide Famoxadone is an oxazolidinone derivative whose mode of action is known- it inhibits the cytochrome bc1 complex of the fungi stopping the respiratory chain. There are crystal structures of famoxadone bound to the (Qo)active site of the bc1 complex- structures 1L0L (0 is zero), 2FYU, 3L74. Eaberry (talk) 03:36, 28 November 2010 (UTC)

No, now I see that not all oxazolidinones contain oxazolidine-dione.Eaberry (talk) 03:43, 28 November 2010 (UTC)

What are the side effects of Oxazolidinones used as antibiotics ?
Are side-effects different than other protein synthesis inhibitors ? - Rod57 (talk) 21:53, 14 January 2013 (UTC)

Cycloserine is really a very different type of compound
I have to bring this up as I've had this article used as evidence couple times now for a point I don't think is valid. When I say oxazolidinone antibiotics were only discovered in the late 1980s, people roll out cycloserine. Technically an oxazolidinone (iso-oxazolidinone, actually), it has different origins, mechanism of action, and is chemically much simpler, and I don't think it's a good idea to lump it in with linezolid and followers. It ends up in this group more as a consequence of nomenclature, not chemical properties, history, or biological activity. While it should probably be in the article, I'm not happy with how it's currently presented. Scaldwell17 (talk) 16:29, 9 January 2015 (UTC)

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