Talk:Allantoin

Untitled
Is it a product of purine metabolism in humans? Mccready 13:59, 12 February 2006 (UTC)

Vitamin U - What is true?
This chemical has been speculated by some to be associated with activity related to the proposed Vitamin "U" (thought by some to be methylmethionine-sulfonium chloride) and both chemicals appear to be present in vegetables or derivable from other compounds in vegetables such as cabbage and may be related. It has been speculated that this chemical or one of its derivatives/origins might actually be vitamin "U", which is speculated to have anti-ulcer properties, among other potential benefits. However, there does not seem to be concensus as to which chemical is providing the benefits that have been observed, either of which could ultimately be labled Vitamin "U", and that is if vitamin "U" is ever accepted by mainstream science to actually be a vitamin, and of course if any of these chemicals is actually the one providing the benefits and not another chemical or a combination of them. It may even be possible that all of them assist in the benefits perscribed to them in cooperative, different, or identical ways. Currently, many scientists appear to either reject these posibilities in favor of other research and theory, reject the idea that Allantoin has anything to do with methylmethionine-sulfonium chloride or the search for Vitamin "U", reject the entire idea of there being a Viamin "U", propose that there is a Vitamin "U" but that it is not truly a vitamin but rather a quasi/sub-vitamin, etc., that methylmethionine-sulfonium chloride can only be Vitamin "U", or dispute the observed benefits of any of these chemicals from noteable or other sources, thereby leaving these issues up to debate and with conflicting evidence and vast public/promoional differences in opinion. See: S-Methylmethionine (The Wikipedia search result for Vitamin "U".) I would appreciate any additional clarifying data regarding this chemical and/or Vitamin "U" and/or any possible link or complete misrepresentation this chemical may have obtained in regard to a Vitamin "U" that anyone could provide. i.e. facts and myths of this chemical, its origins/derivitives, and vitamin "U". Borghuman


 * http://www.chrontourage.com/gyrobase/Issue/column?oid=oid%3A390507
 * 1952, unknown cabbage juice substance, peptic ulcer therapy, not strictly a vitamin, Dr. Garnett Cheney - no sources, but as the first 'piece' I've read on vitamin u I found it helpful JetheroTalk 02:07, 17 April 2007 (UTC)

So.. just saw a comersial...about wrinkle cream...i allways google strange words...cream producers says allantoin comes from snails...is that true ?

More to work on for this page
Allantoin was the first or one of the first, plant compounds to be synthesized for medical use. It is used in over the counter scar cream and prescription herpes medications.

Allantoin is produced from brain trauma, I believe. Many plants are high in allantoin, including comfrey and plantain (plantago major). Weightlifters may ingest comfrey or plantago major as a means of 'bulking up' quickly without the use of steroids or other dangerous drugs.

Allantoin breaks down more quickly at high temp. Unbalanced PH (high or low?) speeds allantoin breakdown, and there is a patent related to storage of allantoin in an appropriate medium.

Rhodescus 16:50, 21 June 2007 (UTC)

Thoughs on Biological action of allantoin, herbal history
Allantoin is widely known as a 'cell proliferant'. The official explanation appears to be that the compound speeds (somehow) the traversal of proteins across cell membranes, allowing tissue to grow more quickly. Allantoin is a product of metabolism and of trauma (being produced via trauma in the human brain.)

Relatively non-toxic plants with high concentrations of allantoin are typically known as 'alteratives' (along with high-vitamin plants.) Alterative is a western (european/american) herbal designation which indicates an 'overall' contribution to good health. This leads to a high number of green leafy plants being listed as 'alteratives'. Plants with allantoin also tend to be listed as healing agents, and for use on boils and ulcers.

Rhodescus 17:03, 21 June 2007 (UTC)

"Also known as" -- all of these need citations or need to be deleted
These all need citations as they are likely comibinations of allantoin and something else. I've already deleted "Alcloxa" because it is a complex of allantoin plus aluminum hydroxide:. Softlavender (talk) 00:54, 9 August 2012 (UTC)


 * "Aldioxa" is an aluminum salt of allantoin: . Deleted from aka's. Softlavender (talk) 00:14, 10 August 2012 (UTC)


 * "Hemocane" has absolutely nothing to do with allantoin: . Deleted from aka's. Softlavender (talk) 00:21, 10 August 2012 (UTC)


 * Vitamin U has nothing in common chemically with Allantoin. Deleted from aka's. Softlavender (talk) 00:30, 10 August 2012 (UTC)
 * Actually, contrary to what the article Vitamin U says, "Vitamin U" is a vague, ill-defined term, with no universally accepted meaning. The expression has been used to refer to a number of different substances, with little in common other than being contained in raw cabbage, and allantoin is one of them. JamesBWatson (talk) 12:21, 4 June 2013 (UTC)

Formula
Can anyone explain why the quoted formulas, C4H6N4O3, includes H6, while the molecular structure diagram appears to show only 5 hydrogen atoms? Is there some other hydrogen atom nit explicitly shown, or is one or other of the versions given wrong? Google searches have shown many web sites show either or both of the same formula and structural diagram as in this article, but that is no guarantee of correctness, as they may all have been copied from one another, going back to a single erroneous source. JamesBWatson (talk) 12:18, 4 June 2013 (UTC)


 * There is one hydrogen atom hidden in the core of the Y structure (CH4 - 3 bonds, voila). See 3d structure here:http://www.chemspider.com/Chemical-Structure.199.html — Preceding unsigned comment added by Linda Martens (talk • contribs) 14:52, 29 December 2013 (UTC)

“most mammals except humans and other higher apes” vagueness
I checked the citation for “during development in most mammals except humans and other higher apes[vague]” but the article costs money. Also, it was written in 1944, they may not have said Hominidae or great apes specifically. Somebody with access to the article can check, and I can look for a better citation. Dogshu (talk) 17:44, 29 August 2019 (UTC)


 * The link you provided simply says it's widely accepted but none of the available citations it gives are about primates. Can you find the paper by J. Kellin from 1959? 2600:1700:B270:20F0:19F3:B5C7:3FDB:D650 (talk) 09:37, 24 January 2023 (UTC)

Dubious boiling point 248 deg C over decomposition temperature
A lot of this article is highly dubious and I don't have my login credentials right now, because I am experiencing some technical difficulties.

I pick one of the more patently obvious inconsistencies: for melting point, it say "decomposes" and gives 230 degrees C. Then it **includes a boiling point** oddly, at 478 degrees C. Compounds that decompose instead of melting do not exist as a liquid (not pure, not at STP), the fact that this information is typically included where melting point would be written is a convention. Heat-induced decomposition is not related to melting, but it is analogous as a "maximum handling temperature". This information is also totally uncited in the article. Also, this chemical looks a whole lot like it will never survive boiling, based on my years studying organic chemistry. It can form lots of hydrogen bonds and is "kind of big", so the boiling point would be high, and it contains multiple structural features that have mechanisms to decompose (break apart and rearrange) at high temperatures. 209.94.144.13 (talk) 17:02, 24 November 2020 (UTC)