Talk:Antibody–drug conjugate

Linkers
Need more on the linkers eg MCC, what they are, how they dissolve ... Rod57 (talk) 09:39, 18 January 2011 (UTC)

One source [http://pubs.acs.org/doi/abs/10.1021/bc9002019 Antibody−Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies. 2010] not free.

It seems SeaGens linkers are non-cleavable which can sometimes be advantageous.Seattle Genetics and Genentech. Rod57 (talk) 11:29, 29 April 2011 (UTC)

ADCs using paclitaxel
ADCs using paclitaxel : Synthesis and Preliminary Biological Evaluation of High-drug Load Paclitaxel-Antibody Conjugates for Tumor-targeted Chemotherapy. Rod57 (talk) 00:38, 24 March 2011 (UTC)

AN-152 not an ADC
The toxin is targeted by linking it to LHRH which binds to LHRH receptors on the target cells. Is there a name for this type of targeted therapy ? - Rod57 (talk) 12:27, 14 June 2011 (UTC)

speed of internalisation and stability of link
Sometimes (as in Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematological malignancies) a less stable link is better when the drug/target is more rapidly internalised. - Rod57 (talk) 17:10, 31 October 2011 (UTC)

Major changes - not discussed
Sometime in 2013 it looks like there have been major changes with a lot of content removed without any apparent discussion here. I'd like to reinstate the lists of ADCs in clinical trials - here or should it be in a separate article ? - Rod57 (talk) 13:07, 12 August 2014 (UTC)


 * The pre-June 2013 old page seemed NPOV but the new page seems very POV with unjustified omissions and change of emphasis. Looks like much of the new material has been based on marketing materials or advertisements from one of the ADC vendors. Needs more investigation. - Rod57 (talk) 13:01, 21 April 2015 (UTC)

IMMU-132 etc for list

 * Sacituzumab govitecan Sacituzumab Govitecan (IMMU-132) - (FDA Breakthrough therapy for TNBC, on top of Fast Track, and Orphan drug) - has phase 2 clinical results.
 * anetumab ravtansine(BAY94-9343) for mesothelioma got into at least phase I.
 * ADCT-301 has started phase I for AML - Rod57 (talk) 23:30, 15 February 2016 (UTC)
 * Iomab-B (aimed at CD45 for AML) - IND Dec 2015, Phase III trial agreed with FDA.Medpace to run Ph III trial of blood cancer ADC for Actinium. March 2016 -
 * ARX-788 (aimed at HER2) is registered for phase-1.A Dose-escalation Study of ARX788, IV Administered in Subjects With Breast Cancer With HER2 Expression and trial has started - what payload? - Rod57 (talk) 15:38, 28 March 2016 (UTC)

Preclinical
mentions HDCs (Humabody-DC) based on VH fragments. - Rod57 (talk) 16:31, 15 February 2016 (UTC)

External links modified
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Lancet
For cancer 10.1016/S0140-6736(19)31774-X JFW &#124; T@lk  07:52, 2 September 2019 (UTC)

Problem in the article: creating the abbreviation iADC but not explaining it
Right now the wikipedia article has this:

"The first immunology antibody-drug conjugate (iADC), ABBV-3373, is undergoing clinical trials for participants with moderate to severe rheumatoid arthritis.[16]"

I tried to search for iADC, and found the abbreviation a few times (via google search) - but never a clear definition of that abbreviation. I believe wikipedia needs to adhere to stricter standards, and define such articles. Right now it reads a bit like an advertisement; I think what has to happen is to define the word, also add who coined it if possible, and when. It is not a good idea to add new articles, but not explain them, or link to in-wikipedia to explain that article on wikipedia. Right now (January 2020) we do not have any explanation for that term iADC, which is not ideal in my opinion. 2A02:8388:1641:8380:E1C:C3B5:304A:1703 (talk) 21:20, 30 January 2020 (UTC)