Talk:Carbidopa/levodopa

2007 comments
I think merging these two articles is a bad idea - they're not the same. Levodopa is part of the drug that constitutes Sinemet; Carbidopa is the other half. Together they constitute Sinemet. There's overlap, but they're not the same. This article should discuss WHY this combination is useful in treating parkinson's disease. The answer, by the way, is that dopamine has bad side effects when administered systemically. We don't want to simply give people dopamine because they'd have severe dyskinesic side effects. Besides, the blood-brain barrier is impermeable to dopamine. However, the blood-brain barrier is somewhat permeable to L-DOPA (aka levidopa), and the body converts levidopa to dopamine. We don't want the body to convert all that levidopa into dopamine systemically (outside the blood brain barrier), which is why we administer the carbidopa at the same time. Carbidopa helps prevent such systemic conversion into dopamine. Administering this combination of drugs allows for lower dosing of levidopa and fewer side effects.

As it stands, this article just needs to be cleaned up a lot and rewritten. Cajolingwilhelm 01:22, 26 January 2007 (UTC)

Sinemet ratio
Anyone know the ratio of Carbidopa to L-DOPA in Sinemet? —Preceding unsigned comment added by 98.70.63.145 (talk) 21:47, 25 November 2010 (UTC)
 * Found my own answer, and leaving it here for others.  I should have just looked at the packaging in the first place. As of today (Nov 2010):
 * Sinemet 25-100 has a 1:4 ratio of carbidopa (25mg) to levodopa (100mg)
 * Sinemet 10-100 has a 1:10 ratio of carbidopa (10mg) to levodopa (100mg)
 * Sinemet 25-250 has a 1:10 ratio of carbidopa (25mg) to levodopa (250mg)
 * Apparently 100mg of carbidopa per day can competitively saturate peripheral L-Amino Acid Decarboxylase (compared with levodopa)  --98.70.63.145 (talk) 22:04, 25 November 2010 (UTC)

Why no precautions?
Is the use of these drugs totally benign? Nothing is listed here about the precautions and drug interactions of taking these substances. —Preceding unsigned comment added by 69.118.211.11 (talk) 04:33, 5 January 2011 (UTC)

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Etymology of the name "Sinemet": Latin "sine" + "emet"
The name "Sinemet" is (most likely) a combination of two Latin words: "sine" which means "without", and "emet" which means "vomiting". Sinemet is a combination of levodopa, which reduces the symptoms of Parkinson's but causes severe nausea and vomiting if taken alone, plus carbidopa, which prevents the nausea and vomiting. So by taking Sinemet, you get the benefits, without vomiting.

This would be a nice little factoid for readers to know, and it seems quite obviously true, but unfortunately, the only source I can find probably doesn't meet the standards for reliability required by Wikipedia. So I'm just noting it here in the Talk page; if anyone can find a really good source, please add this to the body of the article, perhaps in the "History" section.

Here's the NON-reliable source:

https://threadreaderapp.com/thread/1093977481693007872.html

Happy New Year, HandsomeMrToad (talk) 06:38, 27 December 2019 (UTC)