Talk:Desmopressin

Re: Digestion of desmopressin tablets & comparisons between forms - Article incomplete
If someone could include an explanation of why this synthetic peptide hormone is not destroyed in the digestive tract, I would appreciate it. Oxytocin, a very similar peptide hormone, is destroyed in the digestive tract, as are many others. What is it that allows the desmopressin to remain in tact when ingested in tablet form? Also crucial - is the nasal form shorter acting? —Preceding unsigned comment added by JasperA (talk • contribs) 09:06, 13 December 2007 (UTC)

Nootropic properties?
I saw an online pharmacy offering a nasal spray containing vasopressin that claimed that it improved memory function. I hope that someone more knowledgable than I can write sa segment about this. Here is what the website says:

Description Brand name: Minirin Active substance: Desmopressin Packaging: nasal spray 10mcg per dose Shipped from: India Desmopressin improves the brain?s ?filing mechanism?, allowing memories to be recalled quickly and easily

Desmopressin is the synthetic version of vasopressin, a peptide hormone found naturally in the brain and partly responsible for ?inserting? memories in the hippocampus, the region of the brain where memories are stored.

Desmopressin rapidly improves short-term memory and enhances memory imprinting. Desmopressin is sometimes used for the treatment of diabetes insipidus, a condition of frequent urination and extreme thirst. In some countries, Desmopressin is used for amnesia and to treat narcotic-related mental problems.

Whereas many common memory drugs improve the capability to remember past events easier and faster, Desmopressin helps us to remember future events better! That is, taking Desmopressin before an event, firmly imprints the event in the mind, enabling it to be recalled with more detail later. Consequently, Desmopressin is of particular benefit before lectures, business meetings and other such occasions.

Dosage: Insert one or two sprays into each nostril (each spray contains 10mcg) 15 minutes before recall or concentration is required. The effect can take place within seconds and last for up to several hours.

Side effects: Nausea and headaches

Caution: Desmopressin should be used infrequently. It should be avoided completely if you suffer from cardiovascular problems. Avoid the intake of large amounts of liquids as Desmopressin tends to decrease the frequency of urination. —Preceding unsigned comment added by 207.200.167.62 (talk) 20:05, 1 February 2010 (UTC)


 * ridiculous. someone is selling a synthetic hormone with potentially severe side effects to "improve memory". just stay away from such bumpf 70.51.83.211 (talk) 14:05, 17 August 2022 (UTC)

Mode of Action
I changed the original text in this article. The article said that DDAVP causes release of vWF and t-PA through action on the V1a receptor. My research shows that it acts through V2 receptors on the endothelium, so I changed it to V2. Here's a reference: http://www.ncbi.nlm.nih.gov/pubmed/12871401. It goes to an article entitled "Cellular mechanisms of the hemostatic effects of desmopressin (DDAVP)." — Preceding unsigned comment added by 128.125.179.194 (talk) 05:49, 30 January 2012 (UTC)

Ehlers Danlos Syndrome IV, Vascular, Arterial Ecchymotic
Would someone be so kind as to enter a reference regarding the use of Desmopressin in case of hemorrhage for those with Ehlers Danlos Syndome IV, vascular type. It has been used with success, especially to obviate/stop post partum hemorrhage, which is a major cause of maternal death. Many thanks if you can assist. — Preceding unsigned comment added by 101.171.170.167 (talk) 07:03, 3 April 2014 (UTC)

Brand name
Per WP:PHARMMOS generally the first brand name is included. Doc James (talk · contribs · email) 02:19, 28 October 2018 (UTC)