Talk:Dextroamphetamine

Dexamfetamine
The article currently uses the name 'dexamfetamine' intermittently as a synonym. Presumably this is an Americanism, but it's nonstandard usage and clashes with the rest of the article. I'm not even sure this is an AE/BE issue, more a case of editors using local terminology without thinking. --Ef80 (talk) 01:43, 8 March 2015 (UTC)
 * - should be consistent now. Dextroamphetamine is the United States Adopted Name, while dexamfetamine is the British Approved Name, so it actually does reflect American vs British nomenclature for the drug.  Seppi  333  (Insert 2¢ &#124; Maintained) 03:51, 8 March 2015 (UTC)
 * Interesting! I'm British and haven't encountered dexamfetamine, but then I'm not a pharmacist. Traditionally American drug nomenclature favoured 'f' and British 'ph', hence my misguess. Thanks for sorting it out. --Ef80 (talk) 18:42, 18 March 2015 (UTC)

Censoring edits to Dextroamphetamine pharmaceuticals and prodrugs
In the edit summary Seppi said, "this needs to be cited before it's decensored."

Why does it need to be cited before it's decensored? Most of this is already noted in the several amphetamine articles. For remaining concerns a citation needed tag exists.

I can and have added some citations regarding when agents were approved or discontinued, and current status. I cannot say when Benzedrine was discontinued except that a published article in 1976 which touted Dexedrine as superior caused sales to collapse. SKF didn't use "XR" but used "spansule" which is a registered trademark. Rights to "spansule" were obviously transferred to Amedra. If you explore my FDA citations, pay attention to the application numbers to distinguish between IR and XR forms.

My original intent was to signify Vyvanse and Dyanavel are not available as generics. I saw no need to cite patent information.

Seppi also said, "It probably shouldn't be in a note due to its length."

from WP:SRF ...notes are used to add explanations, comments or other additional information relating to the main content. One of the reasons they may be used is to avoid making the text too long or awkward to read.

Making individual notes or even citation numbers would disturb the look and feel of the table. This was better handled by a single note at the title. The table makes bad inferences. Dexedrine is not available, the time release form of Dexedrine, called Spansules is available. Dexedrine was available in 1937, Dexedrine Spansules in 1976. If Spansules is cut some note is in order. Unless I missed something, Shire discontinued Adderall tablets. Correction: I was mistaken and am removing the Adderall IR discontinued part.

I'm reverting, well manually reverting with citations. I agree that notes typically should be shorter. But notes of various lengths occur and for reasons above this seems reasonable. I hate censorship. Let's try and find a solution instead. (Weren't you taking a hiatus!) — Box73 (talk) 05:35, 30 December 2015 (UTC) Correction above — Box73 (talk) 09:30, 30 December 2015 (UTC)
 * Thanks, looks good now. I don't particularly care that much about it being in a note, although I find it odd to have a full paragraph inside one.  My only real concern was the text was uncited.  Anyway, I didn't mean to suggest I wouldn't be editing at all over the holidays, merely less active and less likely to promptly respond on WP unless I get an email notice.  Seppi  333  (Insert 2¢) 18:21, 30 December 2015 (UTC)

Chemical Structure
It has come to my attention that the chemical structure of Dextroamphetamine in this article differs from the structure presented by PubChem under the U.S National Institute of Health Website;

The amine is linked with the wedge bond as opposed to the methyl being linked with the wedge bond as presented in this article. I was hoping the community could verify the structure in this article as I'm afraid my knowledge is too limited to do so.

Linked is the official dextroamphetamine page from the Open Chemistry Database (PubChem)

Cheers, Nukjo (talk) 17:32, 22 June 2016 (UTC)

External links modified
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External links modified
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Image captions in Uses section
I’ve just submitted an edit, but I thought it was worth bringing up here. I changed the captions of the first two images in this section (of the generic dextroamphetamine tablets, and the Dexedrine Spansules) to more accurately reflect the images. Note that in my edit summary I mistakenly refer to the captions as descriptions, apologies. I’m still new to this, and I’m not entirely certain of a few parts -

- Whether the first image’s caption should include “sulfate” after “Dextroamphetamine” or not, so I left it out of this edit. Also unsure if there can/should be any further clarification made for the first image’s caption, in that the bottles pictured use an alternate spelling of dextroamphetamine, “dexamphetamine” (and if required, of sulfate, “sulphate”), both of which are slightly different from the spellings used throughout the article including my current edit.

- Whether the extra information regarding the sustained-release dosage form, that I appended to the second image’s caption, is perhaps slightly excessive or could be better worded.

I’d appreciate if anybody could reply in the case of my edit needing further alteration, especially if they make such changes themselves, just for the sake of me learning a bit.

As a side note - I haven’t found any solid info to confirm this yet, but the particular medication bottles pictured in the first image are of a generic dextroamphetamine whose label states Sigma Pharmaceuticals, who presumably distributed the medication. I am fairly sure this generic form is no longer distributed in Australia by this company, but rather by Aspen Healthcare/Pharma. I actually happen to be prescribed this exact form of the medication myself (in Australia also), and the bottles I receive from pharmacies when filling the prescription have a very similar label design to the one pictured, except for saying “Aspen Pharma” as the distributor, and having the formatting slightly different. The tablets themselves also have a very slightly different shape. If I do find out it is the case that Aspen’s version has replaced Sigma’s and therefore made the latter obsolete, I’ll make another post here, and can easily update the image with a photo of my own for the sake of being contemporary. Hkstrydr (talk) 16:16, 31 August 2020 (UTC)

Misleading text in 'Medical'
Reviews of clinical stimulant research have established the safety and effectiveness of long-term continuous amphetamine use for the treatment of ADHD.[27][28][29]

The article in reference 27 does not specifically concern dextroamphetamine but studies more methylphenidate, atomoxetine, guanfacine, imipramine/desipramine, clonidine, bupropion and tricyclic antidepressants. By using "general" information on ADHD-medication, it is giving some assumptions regarding the product dextroamphetamine when this might not correspond to reality ! I did not check references 28 nor 29 but suggest that these are checked too and the paragraph be reviewed in order to include only information relevant to dexamphetamine. — Preceding unsigned comment added by 85.127.144.170 (talk) 14:04, 25 September 2020 (UTC)

Annoying broken reference
I hope not to bore everyone over a small detail in an otherwise very appealing article, but I've noticed a rather annoying error at reference 69 or so. It probably originates from a transclusion from the "Amphetamine article", and has been there for a while... I've spent an embarrassing amount of time trying to remove, but Satan clearly jammed that thing good. How would you suggest fixing it? Horsesizedduck (talk) 21:34, 27 June 2021 (UTC)

Average adult clinical doses? Range needed
Doses above 60mg daily considered harmful? 66.135.148.160 (talk) 08:46, 12 January 2022 (UTC)

Isomer reference irrelevant and unsourced
WRT to the following:

" It also shares many chemical and pharmacological properties with human trace amines, particularly phenethylamine and N-methylphenethylamine, the latter being an isomer of amphetamine produced within the human body."

The final phrase might suggestion to some that N-methylphenethylamine functions like amphetamine, but merely being isomers does not point to a structure-function relationship, plus there is no reference so I think the text starting with "the latter..." should be deleted.

Spope3 (talk) 23:46, 25 May 2022 (UTC)