Talk:Docetaxel

Untitled
"docetaxel is considered better than doxorubicin, paclitaxel and fluorouracil as a cytotoxic antimicrotubule agent" - please consider to revise this part.What does it mean "better"? More potent in vitro? What about clinical importance? Should we use docetaxel as 1st line in any indication and hold doxorubicin, paclitaxel and fluorouracil for 2nd line? Gor n bein (talk) 20:36, 23 December 2008 (UTC) Gor_n_bein

Hello.

I've just finished a Drug Review Assignment for the Department of Pharmacology at the University of Auckland, New Zealand. I have now modified the docetaxel article on Wikipedia based on my assignment. I have referenced every statement and everything should be accurate.

I plan to tidy up the following over the next week;

Reference tables Tidy tables Add internal links Reference DrugBox values

I welcome anybody to help with the cleanup, but please discuss any major modifications here so that we don't have to go back and forth.

--Wetrix 10:35, 2 October 2006 (UTC)

Inaccurate portrayal as 2nd line drug
The lead states "Docetaxel has an approved claim for treatment of patients.........who have undergone anthracycline-based chemotherapy and failed to stop cancer progression or relapsed". This may (or may not) be the case in the USA. To state it as the global position is inaccurate - (in Australia the first line treatment for invasive breast cancer is a triple combination including Docetaxel). Misinformation in article on cancer treatments can cause worry to people looking for information on their cancer treatment. And conceivably result in harm to them.

This is one of the WP articles in which accuracy is important. Please consider this before editing. I will tag the article. 124.169.208.109 (talk) 07:00, 17 October 2008 (UTC)

5 FU is not an antimicrotubule agent. It inhibits DNA synthesis not cell division. (Oncology Pharmacist here) —Preceding unsigned comment added by 63.148.191.50 (talk) 15:25, 26 December 2008 (UTC)

misleading treatment regime
Section/"Monitoring and combination with other drugs" states; "Docetaxel is administered via a one-hour infusion every three weeks over ten or more cycles." This may be one possible regime - to describe it as the only option is incorrect and misleading. In Australia the triple combination (TAC) is commonly given in six cycles of 3 weeks each.

My confidence in the accuracy of this article is now zero. 124.169.208.109 (talk) 07:13, 17 October 2008 (UTC) http://www.cancerbackup.org.uk/Treatments/Chemotherapy/Combinationregimen/TAC 124.169.104.133 (talk) 13:54, 4 November 2008 (UTC)


 * The link you have provided describes a triple combination of chemotherapy for *breast cancer* whereas the section you refer to as being incomplete is addressed to the use of docetaxel in the case of androgen independent prostate cancer. Indeed, on the same website that you reference if you click the link to "cancer[s]" and select prostate cancer you find that the standard regimen described on your UK website is the same as in the US -- docetaxel with prednisone every three weeks over 10 or more cycles. What may be misleading is how many people tolerate or live through 10 or more cycles. If you assume good faith in a Wikipedia article about a subject this important, you might think twice before reducing your confidence to zero and re-examine your own information. —Preceding unsigned comment added by 75.31.50.53 (talk) 19:44, 29 December 2008 (UTC)

Removed Disputed Tag
The template had been up at the top of this article since October of 2008. In an article of this size, and having been up for such a long time, I don't think the template was adding anything to the article or warning any readers of anything specific anymore. I think it would be far more useful for individuals to tag specific concerns about factual accuracy where they appear in the article. Do others agree with my decision to remove the template, and my reccomendation about specific concerns being tagged where they appear? Spiral5800 (talk) 15:16, 5 February 2010 (UTC)

Statement of Efficacy
In the intro, it is stated: " Administered as a one-hour infusion every three weeks generally over a ten cycle course, docetaxel is considered as or more effective than doxorubicin, paclitaxel and fluorouracil as a cytotoxic antimicrotubule agent." As has already been pointed out here, flurouracil is NOT an antimicrotubule agent - nor is doxorubicin. I'm not sure about the source from which this statement has been taken, as it is a publication that is not online, but its accuracy is definitely dubious. Thoughts? How should this be fixed? Spiral5800 (talk) 15:40, 5 February 2010 (UTC)

Prostate cancer
Taxotere has been shown to improve survival in cancers resistant to hormone therapy. EU Approval for Taxotere (docetaxel) in Prostate Cancer Article Date: 09 Nov 2004 - 0:00 PDT Ocdcntx (talk) 20:48, 21 February 2010 (UTC)


 * Now mentioned in intro and under applications. Rod57 (talk) 12:28, 10 June 2010 (UTC)

What month in 2010 does the U.S. patent expire?
What month in 2010 does the U.S. patent on Taxotere expire? < 66.167.95.147 (talk) 03:00, 15 March 2010 (UTC)


 * Looking at http://www.accessdata.fda.gov/scripts/cder/ob/docs/patexclnew.cfm?Appl_No=020449&Product_No=001&table1=OB_Rx it seems May or Nov depending on what "PED" means. Rod57 (talk) 12:12, 10 June 2010 (UTC)

March 11, 2011, the US Food and Drug Administration (FDA) approved cancer drug docetaxel, a generic version by Hospira. Taxotere sales were approximately $1.2 billion in 2010. — Preceding unsigned comment added by Ocdncntx (talk • contribs) 21:42, 11 March 2011 (UTC)

External links modified
Hello fellow Wikipedians,

I have just modified 3 one external links on Docetaxel. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
 * Added archive https://web.archive.org/web/20100603164834/http://www.medsafe.govt.nz/profs/Datasheet/d/DocetaxelEbeweinj.htm to http://www.medsafe.govt.nz/profs/datasheet/d/DocetaxelEbeweinj.htm
 * Added archive https://web.archive.org/web/20051228000129/http://medsafe.govt.nz:80/Profs/datasheet/t/taxotereinf.htm to http://www.medsafe.govt.nz/profs/Datasheet/t/taxotereinf.htm
 * Added tag to http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4814470.PN.&OS=PN/4814470&RS=PN/4814470
 * Added archive https://web.archive.org/web/20060428011003/http://products.sanofi-aventis.us:80/Taxotere/taxotere.html to http://products.sanofi-aventis.us/Taxotere/taxotere.html

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