Talk:Ebola

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This article was the subject of a Wiki Education Foundation-supported course assignment, between 18 August 2020 and 4 December 2020. Further details are available on the course page. Student editor(s): Aced 24.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 20:01, 16 January 2022 (UTC)

Ebola virus link to T-cell depletion
Could someone, please, insert the following text into the main article?

A new study done at University of Texas Medical Branch at Galveston sheds new ligh on the way the Ebola virus attacks immune system of the infected person by disabling T cells.

In the said study, it has been demonstrated "that both viral mRNAs and antigens are detectable in CD4+ T cells despite the absence of productive infection. A protein phosphatase 1 inhibitor, 1E7-03, and siRNA-mediated suppression of viral antigens were used to demonstrate de novo synthesis of viral RNAs and antigens in CD4+ T cells, respectively. Cell-to-cell fusion of permissive Huh7 cells with non-permissive Jurkat T cells impaired productive EBOV infection suggesting the presence of a cellular restriction factor." It was "determined that viral transcription is partially impaired in the fusion T cells" and "that exposure of T cells to EBOV resulted in autophagy through activation of ER-stress related pathways. These data indicate that exposure of T cells to EBOV results in an abortive infection, which likely contributes to the lymphopenia observed during EBOV infections."

The above quotes come from:

Patrick Younan, Rodrigo I. Santos, Palaniappan Ramanathan, Mathieu Iampietro, Andrew Nishida, Mukta Dutta, Tatiana Ammosova, Michelle Meyer, Michael G. Katze, Vsevolod L. Popov, Sergei Nekhai, Alexander Bukreyev. Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection. PLOS Pathogens, 2019; 15 (10): e1008068 DOI: 10.1371/journal.ppat.1008068 — Preceding unsigned comment added by 172.88.197.74 (talk) 16:07, 27 February 2021 (UTC)
 * ❌. We much prefer a secondary source for medical articles (see WP:MEDRS). Also, you need to simplify that down into layman terms, aka defining what all of those acronyms mean. ◢  Ganbaruby!   (Say hi!) 01:47, 9 March 2021 (UTC)

Semi-protected edit request on 13 June 2022
The paragraph directly under the Causes section of the article states that "EVD in humans is caused by four of five viruses of the genus Ebolavirus," and goes on to talk about each of these five variants. The Wikipedia article for Ebolavirus, however, states that there are six different species of in the Genus Ebolavirus, with the addition of Bombali Ebola virus to the five mentioned in the paragraph. All sources used in this paragraph were published prior to this species identification in 2018, and as such would not have listed this species. As such I believe that this section should be updated to include this new species. A suggestion for possible edits (without updated references) to this section is below:

Cause
EVD in humans is caused by four of six viruses of the genus Ebolavirus. The four are Bundibugyo virus (BDBV), Sudan virus (SUDV), Taï Forest virus (TAFV) and one simply called Ebola virus (EBOV, formerly Zaire Ebola virus). EBOV, species Zaire ebolavirus, is the most dangerous of the known EVD-causing viruses, and is responsible for the largest number of outbreaks. The other two viruses, Reston virus (RESTV) and Bombali ebolavirus (BOMV), are not known to cause disease in humans, but have caused disease in other primates. All six viruses are closely related to marburgviruses.

FATCullen (talk) 04:16, 13 June 2022 (UTC)


 * ✅ Aaron Liu (talk) 03:57, 8 July 2022 (UTC)

Semi-protected edit request on 3 September 2022
Add a record for the August 22, 2022 Ebola outbreak.

The National Institute for Biomedical Research (INRB) of the Democratic Republic of the Congo (DRC) announced on August 22, 2022, that a fresh Ebola virus case had been identified in the city of Beni, a town located in North Kivu. According to a statement from Placide Mbala, head of the Pathogen Genomics Laboratory at the National Institute for Biomedical Research (INRB), testing revealed that the case was genetically connected to the outbreak that occurred in the 2018–2020 academic year in the North Kivu and Ituri provinces and claimed approximately 2,300 lives (Ebola Zaire strain). Sequencing carried out at the Rodolphe Mérieux Laboratory of INRB in Goma confirmed the genetic link and thus determined it was not a new spillover event.

Placide Mbala also stated, "Our initial findings indicate that this case likely represents a new flare-up of the 2018-2020 North Kivu/Ituri outbreak, initiated by transmission of Ebola virus from a persistently infected survivor or a survivor who experienced a relapsed." Investigations are ongoing to determine the source. According to the statement, at least 131 contacts have been found, including 60 front-line healthcare providers, 59 of whom have received the Ebola vaccine. However, the WHO reports that A total of 134 hospital contacts (60 health care personnel and 74 co-patients) were been identified.

The test was administered using reverse transcription polymerase chain reaction (RT-PCR) testing on oropharyngeal secretions and sent to National Institute for Biomedical Research, Beni, which revealed a positive result. The sample was analyzed at the Rodolphe Mérieux INRB Laboratory in Goma for quality control purposes, and on August 16, 2022, RT-PCR results were confirmed. The body was given to the family before the test findings were known, and it was then buried on August 16, 2022.

The WHO sent supporting health officials to investigate the case and prepare for a possible outbreak during the ongoing analysis. They worked with local health authorities to start contact tracing, ensuring proper infection prevention and control measures were in place. They also started an Ebola awareness campaign in the area. The WHO also stated that "the current resurgence is not unexpected given that EVD is endemic in the country and Ebola virus is present in animal reservoirs in the region."

The re-emergence of Ebola is a significant public health concern in the Democratic Republic of the Congo, and there are still gaps in the country's capacity to recover, prepare and respond to outbreaks. The outbreaks in the country unrelated to the August 2022 Ebola outbreak (COVID-19, cholera, measles, polio, yellow fever, monkeypox, etc), as well as other humanitarian factors (armed groups, refusal of outbreak control measures, etc), have strained the Beni health system and its resources.

The WHO described the national risk as high; however, the regional and global levels were assessed as moderate to low, respectively.

Isacc Barker (talk) 19:46, 3 September 2022 (UTC)


 * Red information icon with gradient background.svg Not done for now: This is written like a news article. Please see WP:NOTNEWS and reopen your request after you have refactored it. Aaron Liu (talk) 11:41, 15 September 2022 (UTC)

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