Talk:Ernest Duchesne

Untitled
There were fifteen years between his doctoral defense and his death. Was he in the army the whole time? What was he up to? Rmhermen 06:08, Apr 3, 2004 (UTC)


 * I've just found a rather detailed chronology of his life at http://www.bium.univ-paris5.fr/sfhad/vol8/article09.htm


 * Here is a quick translation from French:


 * He was born May 30, 1874 in Paris
 * 1894, he is admitted at "l'Ecole du Service de Santé Militaire de Lyon" (Military Health Service School of Lyon).
 * 1897, he defends his thesis at age 23.
 * 1898, one year internship at Val de Grace.
 * 1899, he is appointed "Médecin Major de 2eme classe au 2 nd Regiment de Hussards de Senlis".
 * 1901, he marries Rosa LASSALAS, from Cannes. She dies 2 years later of tuberculosis.
 * 1904, he contracts an unknown pulmonary disease.
 * 1907, he is discharged from the army and sent to a care center in Amelie les Bains.
 * April 12, 1912, he dies at age 37.
 * He is buried next to his wife in Cannes cemetery.


 * Delta G 07:52, 3 Apr 2004 (UTC)

Better references
We need better references than this. DanielDemaret 18:08, 30 March 2006 (UTC)

JMcc150 gave me a better reference, so I added it.DanielDemaret 18:57, 30 March 2006 (UTC)

Speculation on WWI?
The text says: "His own discovery might have saved him, his wife and millions of other lives in World War I." And the word "might" makes the sentence true. However, Fleming had several more problems after his discovery. It was difficult to grow penicillium mold and having made it, it was even more difficult to refine it. It was still not that easy even after the work of Florey and Chains work.

Here is a speculation of my own. If it had been easy to grow, and Duchesne knew about the mold, then why not use it on his wife and on himself?

And the next question, of course is how far we should speculate in this article. I shall let it stand, but I raise the question on this particular phrase.

I know why Flemings's work was largely ignored, it was well documented. However, is there any information out there on why Duchesnes work was ignored?

It is very interesting that that he discovered the properties this early. Perhaps there are even earlier discoveries, since he found out about it from arab stable boys? Perhaps some Arab doctors? Perhaps from Ibn Sina, even?DanielDemaret 05:52, 31 March 2006 (UTC)


 * So wasn't it actually discovered by the Arab stable boys, not Fleming or Duchesne? Possibly centuries earlier?

Typhoid
It must have been a different strain of peniccilin than that which Fleming found, since Flemings version did not cure Typhoid, but this one did.DanielDemaret 06:45, 31 March 2006 (UTC)

Glaucum
Today, the strain discovered by, Notatum Fleming is the one that produces antibacterial medicin as far as I can see. I can see other uses for Glaucum, but I have not yet found it for antibacterial purpuses. Any help?DanielDemaret 07:53, 31 March 2006 (UTC)

Pasteur
I have seen many references to the fact that Pasteur himself had noted that Notatum suppressed bacterial growth, but I am looking for better references.DanielDemaret 07:53, 31 March 2006 (UTC)

History of antibiotics
This looks like a good reference too

http://www.molbio.princeton.edu/courses/mb427/2001/projects/02/antibiotics.htm

While Fleming generally receives credit for discovering penicillin, in fact technically Fleming rediscovered the substance. In 1896, the French medical student Ernest Duchesne originally discovered the antibiotic properties of Penicillium, but failed to report a connection between the fungus and a substance that had antibacterial properties, and Penicillium was forgotten in the scientific community until Fleming’s rediscovery. DanielDemaret 07:59, 31 March 2006 (UTC)

WikiProject class rating
This article was automatically assessed because at least one article was rated and this bot brought all the other ratings up to at least that level. BetacommandBot 03:11, 27 August 2007 (UTC)

Missing text
There seems to be some text missing from this section:

Intrigued, Duchesne prepared a solution of the mould and injected it into a so showed that an animal inoculated with a normally lethal dose of typhoid bacilli would be free of the disease if the animal was also inoculated with Penicillium glaucum. — Preceding unsigned comment added by 24.19.248.239 (talk) 08:32, 21 November 2012 (UTC)

It should have talked to guinnea pigs. I updated it. --Pg8p (talk) 11:39, 10 August 2014 (UTC)

This Article Sucks
Okay, I spent a short blip trying to make this article suck a little bit less. To be clear, there's a bunch of uncited, potentially incorrect material in place, including missing text from 2012. The arab saddle boy thing, to be clear, may be true -- I found it mentioned in a random book, but I'm concerned that book may have looked at this wikipedia article for it's source. If there is someone that speaks french and english, this is a PERFECT opportunity to look at the french version of this article and translate that for the english page -- it's in much better condition over at fr.wikipedia.org. Hopefully this message won't get lost in the mix, somebody who knows this stuff needs to do a thorough review of this article. --Pg8p (talk) 11:39, 10 August 2014 (UTC)

Error
At present, this article reads as follows:

''In Duchesne's landmark thesis, Duchesne begins testing the effect of tap water on mold finding mold is significantly diminished when exposed to French tap water. After detailing 19 different experiments, Duchesne concludes the presence of Penicillium glaucum inhibits bacterial growth:'' "Toutes ces expériences aboutissent aux mêmes résultats: la présence de bactéries dans un milieu où l'on cultive des moisissures est pour ces dernières une cause de destruction rapide, quand bien même ces moisissures auraient eu le temps de s'accoutumer au milieu nutritif avant l'apport de microbes."

It is apparent that whoever added this passage can't read French because it states precisely the opposite of what the editor claimed that it states. The translation is as follows:

All these experiments lead to the same results: the presence of bacteria in the medium where one cultures molds is, for the latter, a cause of [their] rapid destruction, even if the molds had had time to become accustomed to the nutritive medium before the introduction of the microbes.

In other words, the bacteria kill the molds, not vice-versa. (The original passage appears here: (Duchesne, 1897), p. 36.)  So I will delete this passage.

However, the other quoted passage is more relevant. I will provide a translation of it. VexorAbVikipædia (talk) 00:24, 3 April 2016 (UTC)

Duchesne discovered Patulin, not Penicillin.
Duschesne's filtrates were observed to kill gram negative bacteria, however penicillin has little or no effect on gram negatives, due to the lack of a cell wall. Penicillin is only effective against gram positive bacteria as its mode of action is to lyse the bacterial cell wall. This causes cytolysis and therefore cell death.

I'm sure there are more legitimate sources to be found. I've could've have written this just from basic molecular biology knowledge, but I was prompted to do so by this article. — Preceding unsigned comment added by 143.167.226.88 (talk) 17:20, 25 May 2016 (UTC)

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