Talk:Leptospirosis

Untitled
http://www.leptospirosis.org/medical/infection.php "There is no human vaccine licenced for use in Europe, Asia or the USA."

I found this page quite hard to digest as the text comes as a large unbroken chunk. I would suggest adding a table of contents and splitting the page into various chapters (features, diagnosis, treatment) as for example, the meningitis page. --Anon September 07, 2005

I second that. A lot of information is mentioned several times, and it's quite messy. As far as I can make out, is also all correct (I work for the WHO/Royal Dutch Institute Lepto-dept). I'm willing to 'correct' any changes made, if somebody else starts the editing... --Bluuurgh 16:02 Thursday, October 13 2005 (UTC)
 * I cleaned up the page somewhat, maybe someone can go through and clean up my clean up? --CDN99 15:48, 14 October 2005 (UTC)

To me, the many jumps back and forth between Leptospirosis in humans & Leptospirosis in animals (dogs, primarily) was confusing. At several points it is hard to tell whether the information pertains to humans or dogs. I suggest overall organization along species lines. —Preceding unsigned comment added by 65.200.165.111 (talk) 01:39, 10 March 2011 (UTC)

Medical advice
Regarding the drug dosages you mention, perhaps you should mention where you have obtained these values? Very good article otherwise!

Leptospirosis in animals needs to be a separate article
Although there's good information in this article, it would be much more cohesive if the information about leptospirosis in animals were to be removed and placed in a separate article, perhaps entitled Leptospirosis (animals). It's not entirely clear whether some of the paragraphs in the current version of the article refers to leptospirosis in humans or animals or both. NighthawkJ (talk) 18:13, 10 October 2008 (UTC)

Also, it needs to be updated with modern information: there are new animal vaccinations out, which are supposed to actually be effective and longer-lasting. I can pick up a brochure from my vet next visit, but aside from the name of the manufacturer I don't think it's going to be an authoritative cite. Anybody? 207.178.110.185 (talk) 01:29, 20 November 2008 (UTC)

helllo ok —Preceding unsigned comment added by 61.17.188.95 (talk) 06:30, 18 January 2009 (UTC)

A sentence telling us approxiamtely nothing?
"Approximately 5-50% of severe leptospirosis cases are fatal; however, such cases only constitute about 10% of all registered incidents."

"Approximately 5 to 50%"?! This is an entire order of magnitude! Do half these people die, or just 1 in 20? If there's any data at all, it should be able to approximate a little better than this. But there's no citation. And, I suspect, no data. As is, it reads like hand-waving plucked-out-of-the-air space filler.

"... however, such cases only constitute about 10% of all registered incidents." Well, the approximation's more meaningful, but now we have a subsequent clause trying to tame the prior one, and forcing the reader to do all kinds of mental gymnastics to derive meaning.

I would re-write this in a kinder way, but with no data to support it... well, revert me if I'm wrong, but I think it's better gone.

Thanks The Zig (talk) 00:03, 6 April 2009 (UTC)

Content is overly technical for a general audience
I placed a {technical} tag at the beginning of this article. Even with a significant medical background, I had problems reading it. For the layperson, it probably seems like total gibberish. For example, it starts out discussing "serovars" when they could just as easily have been called "variations". Later on, "aetiotropic" is a nice $3 word that essentially means "antibiotic". There is a big difference between merely wikifying terminology and actually improving comprehension. Thus, the overall tone comes across as just a lot of WP:jargon: "Articles in Wikipedia should be understandable to the widest possible audience. For most articles, this means understandable to a general audience [emphasis in original]." 23:46, 30 August 2010 (UTC)

Season reference needs to be clarified
Can the reference to seasonal occurrence be updated, as the article specifically mentions "August–September/February–March". Are these Northern or Southern Hemisphere references.

Feebee06 (talk) 10:56, 7 November 2010 (UTC)

Veterinary data missing
This article is mostly based on human cases of leptospirosis, so there is no data on symptoms in animals; yet animals get this disease more often than humans IIRC... Arny (talk) 13:35, 28 July 2011 (UTC)

Placement of image
Since my change of relocating the life cycle figure to the History section was reverted, I thought that I should explain why I tried to place it there. The image was originally placed under History by the author of the paper postulating that leptospirosis was the infectious disease that wiped out most of the Native Americans residing in present-day Massachusetts in the early 1600s. Most of the risk factors listed in the image are specific to the Native American lifestyle of the era. According to the caption of the image, "The Native American lifestyle exposed them to the leptospiral life cycle." This hypothesis is described in the History section. For an unknown reason, the image was later moved to the Prevention section. To me, this location doesn't make sense for a figure listing risk factors specific to Native Americans of the 1600s. I believe that the image should be moved back to the History section, where the image was located originally. CatPath (talk) 16:14, 11 April 2014 (UTC)
 * These are still current causes/risk factors. Thus moved to the section on cause. Doc James  (talk · contribs · email) (if I write on your page reply on mine) 10:45, 12 April 2014 (UTC)

Lede and statistics
The prose is a bit rough and in the lede, there is mention of a 50% mortality rate in severe infections, but nothing to place context of numbers of severe infections vs mild to moderate infections. That is partially in the signs and symptoms section. Should we move the statistics of severity to the lede or move the mortality rate of severe infections down to the signs and symptoms section where it mentions 90% are mild and perhaps add moderate case data as well (with citations, of course)? The article in general has loads of good information, but it is somewhat hodgepodged together, I'll try to smooth that out later.Wzrd1 (talk) 02:34, 30 April 2014 (UTC)

Hideyo Noguchi
The Hideyo Noguchi article states that he created the vaccine for this disease but here that is not stated. Which is right? What did he do?

Assessment comment
Substituted at 21:54, 29 April 2016 (UTC)

Tries to improve structure might have lead to unclear references.
Some time after this posting (where "this" obviously refers to the nearest preceding item, the 29 April 2014 substitution), CatPath indeed tried to separate human and (other) animal info, inter alia in this edit, moving much of the content of the Cause section to the Other animals one. Six weeks ago, here, Mathrick marked the remaining text as containing an unreferenced comparative more useful. I do not quite agree with Mathrick's assessment, since the section immediately preceding the 'offending' sentence indeed discussed some serogroup identification using MAT. In general, I think, that it should be permissible to refer to the immediately preceding text for a comparison, without repeating the item you compare to in the same sentence.

On the other hand, before CatPath's edit, the 'offending' sentence was part of a somewhat longer context, forming the following section:
 * Other (more common) lethal infectious strains exist. Genetically different leptospira organisms may be identical serologically and vice versa. Hence, some argue about strain identification. The traditional serologic system currently seems more useful from a diagnostic and epidemiologic standpoint—but this may change with further development and spread of technologies like polymerase chain reaction (PCR).

CatPath: You removed the two italised sentences completely (without reproducing them in Other animals or elsewhere), and just left the third one. I am a bit unsure of whether the discussion of the strain identification also covers humans or not. If it does, perhaps putting back the two italised sentences could solve the problem. Of course, the starting word "Other" then referred to the dog strains, I suppose, whence a slight rewording might be necessary. JoergenB (talk) 15:27, 3 February 2017 (UTC)


 * I removed the first sentence ("Other (more common) lethal infectious strains exist.") because it made no sense in its original and current context. The five most common dog serovars were listed immediately above the sentence before I made my edit.  How can there be serovars (referred to as "strains" in the sentence in question) that are "more common" if the five most common dog serovars are already listed?  Also, I'm not aware of any source claiming that there are pathogenic serovars that not lethal in dogs or humans.


 * The information in the second italicized sentence ("Genetically different...") is already present in the article in the previous paragraph, which states, "A given serogroup is often found in more than one species,...."


 * As for the third italicized sentence ("Hence, some argue about strain identification."), I had no idea what it meant, and I still don't.


 * I'm guessing that whoever wrote the sentence that got flagged by Mathrick meant to say that from a clinical and epidemiological viewpoint, it is more useful to determine an isolate's serovar/serogroup than its species. There are molecular typing methods being developed, many of which involve PCR.  The offending sentence needs to be reworded, and a citation should be added.
 * CatPath (talk) 22:01, 3 February 2017 (UTC)

Puerto Rico 2017
According to CNN, the break down of fresh water supply in the US colony Puerto Rico by the latest hurricane and the post-Hurricane lack of repair are causing an outbreak of Leptospitosis on the island. This should be covered in this artcle. --L.Willms (talk) 08:09, 29 October 2017 (UTC)
 * The outbreak is already covered in the Hurricane Maria article. It doesn't belong here. CatPath (talk) 09:05, 29 October 2017 (UTC)

Pathogenesis
While the flurry of recent changes to the article is welcome, I question some of the content in the Pathogenesis section. The section starts off with a lengthy paragraph detailing results from a number of old experiments demonstrating the activities of various Leptospira proteins in vitro. There is little discussion of how these activities lead to tissue damage. Ditto for the second paragraph: how does the antibody response to LPS/leptospira proteins relate to disease? In my opinion, most of the first two paragraphs should be removed. If the consensus is to retain the two paragraphs, they should at least be updated to reflect more recent research findings. CatPath (talk) 13:33, 1 March 2019 (UTC)
 * Thanks for your opinion. The "pathogenesis" section is trimmed down.Cerevisae (talk) 22:43, 1 March 2019 (UTC)

Lead image


User:Cerevisae not sure about this as a lead image. My concern is the cross eyes which I imagine is unrelated which sort of confuses things. Have clarified the caption a bit. I guess the question is do we just use one eye? Doc James (talk · contribs · email) 14:05, 28 December 2019 (UTC)
 * Yes, I think using one eye is better. Cerevisae (talk) 07:42, 29 December 2019 (UTC)
 * Sounds good User:Cerevisae. Centered it. Feel free to use it in the lead if you wish. Doc James  (talk · contribs · email) 12:40, 29 December 2019 (UTC)

Table, modified Faine's criteria
The table showing the modified version of Faine's criteria was copied almost verbatim from Table 2 in the cited source. Should we be concerned about copyright even though it's a table? CatPath  meow to me  06:40, 4 September 2020 (UTC)
 * I removed the table for now until this question can be resolved. Better to be safe than sorry. CatPath   meow at me  18:14, 4 September 2020 (UTC)

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