Talk:Natural killer T cell

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This article was the subject of a Wiki Education Foundation-supported course assignment, between 28 August 2018 and 21 December 2018. Further details are available on the course page. Student editor(s): Jessica.Kim285.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 05:00, 17 January 2022 (UTC)

It
It would be better to have a figure of an NKT cell rather than an NK cell considering this article is about NKT cells. In addition, you could compare (schematically) NK, NKT and conventional T cells from both mice and humans (showing APC binding: 1.) to T cells in the context of protein:MHC I/II, 2.) to NKT cells in the context of CD1d/beta2microglobulin/glycolipid (aGC reactive or other), 3.)  NK cells alone devoid of co-stim with APC.

And have each with some characteristic receptors (eg. NK1.1/CD161 for NKT and NK, CD3/TcR for NKT and T (but this would be incorporated in the APC-NKT; APC-T interaction schematic); CD4-CD8- (double negative NKT) vs CD4+ (single positive) NKT = in mice. This will show the similarities and differences between conventional CD4/CD8 T cells, NKT and NK cells considering NKT cells are supposed to share features between NK cells (receptor, IFN-g rapid production) and T cells.

Hope this helps.

removed image of NK-cell
found it also disturbing, since article is about NKT cells --Schneedrache 18:35, 21 February 2007 (UTC)

Disambiguation page for NKT
I think a disambiguation page is needed for NKT, as right now it only goes to New Kadampa Tradition. I added a referral on the NEw Kadampa Tradition page for now, but I don't know how to make a disambiguation page, or what guidelines to follow.--corvus.ag 19:28, 5 November 2007 (UTC)


 * Someone has made NKT (disambiguation) and noted it at the start of New Kadampa Tradition. Rod57 (talk) 11:08, 2 November 2010 (UTC)

Incomplete sentence
You have wrote this: "Invariant Natural Killer T (iNKT) cells express high levels of and are dependent on the transcriptional regulator promyelocytic leukemia zinc finger (PLZF) for their development" The sentence is incomplete. They express high levels of what?--Miguelferig (talk) 18:40, 1 January 2012 (UTC)

move
Natural Killer T cell → Natural killer T cell – So that the article's title is correctly capitalized. --JorisvS (talk) 16:23, 28 November 2012 (UTC)
 * Support per WP:NCCAPS. Not controversial. --BDD (talk) 17:20, 28 November 2012 (UTC)

APC Properties of NK cell . Should i add it
Se these papers

http://www.ncbi.nlm.nih.gov/pubmed/15578093

I added a para but was removed as i not cited this url Before adding again i just want to confirm is it ok with all moderators here.

Drajaytripathi (talk) 01:43, 23 June 2015 (UTC)

Review Articles
Here is a list of review articles that could be used to help add to this page. Please feel free to add comments about this bibliography!

Presumed guilty: natural killer T cell defects and human disease: Innate or Adaptive Immunity? The Example of Natural Killer Cells: Natural killer T cells and autoimmune disease: Development of invariant natural killer T cells.: Immcarle29 (talk) 16:51, 2 February 2016 (UTC)

iNKT Section Addition
Hi everyone! I am thinking about extending the iNKT section of this page. Here is a starter draft of what the addition might look like. Please feel free to add and comment!

The best-known subset of CD1d-dependent NKT cells expresses an invariant T-cell receptor (TCR) α chain. These are referred to as type I or invariant NKT cells (iNKT) cells. They are notable in what they are able to respond in an innate-like manner to danger signals and pro-inflammatory cytokines. Once activated, they engage in effector functions within hours. iNKT cells recognize lipid antigens presented by CD1d, a non-polymorphic major histocompatibility complex class I-like antigen presenting molecule. The highly conserved TCR is made of Va24-Ja18 paired with Vb11 in humans, which is specific for glycolipid antigens.[1] The best known antigen of iNKT cells is α-galactosylceramide(αGalCer). These cells are conserved between humans and mice. They are most commonly found in the liver, but are also found in the thymus, spleen, peripheral blood, bone marrow and fat tissue. In comparison to mice, humans have fewer iNKT cells and have a wide variation in the amount of circulating iNKT cells. Unlike other immune cells, iNKT cells are unable to develop immunological immunity.

Currently, there are five major distinct iNKT cell subsets. These subset cells produce a difference set of cytokines, and express distinct transcript factors. The subtypes iNKT1,iNKT2 and iNKT17 mirror Th Cell subsets in cytokine production. iNKT(FH- follicular helper) help provide help to B cells. iNKT's develop in the thymus, and distribute to the periphery. iNKT10 cells secrete IL-10. [2] Once activated iNKT cells can impact the type and strength of an immune response. They engage in cross talk with other immune cells, like dendritic cells, neutrophils and lymphocytes. [3]

While iNKT cells are not very numerous, their unique properties makes them an important regulatory cell that can influence how the immune system develops.[4] They are known to play a role in chronic inflammatory diseases, like autoimmune disease, asthma and metabolic syndrome. In human autoimmune diseases, their numbers are decreased in peripheral blood. It is not clear whether this is a cause or effect of the disease. Absence of microbe exposure in early development led to increased iNKT cells and immune morbidity in a mouse model.Immcarle29 (talk) 05:35, 10 February 2016 (UTC)

External links modified (February 2018)
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Translation request.
Greetings, Could somebody (or somebodies) fluent in "Immunology Jargon" please translate this page into English? I already know some about immunity and cannot wade through it. Let's give casual readers a break! Thank you for your help, Wordreader (talk) 03:40, 7 November 2023 (UTC)