Talk:Neural fold

Suggested Source
Suggested source: Smallman12q (talk) 01:44, 19 March 2013 (UTC)

The following is a proposed introduction for the improved neural fold page that myself, Therazzz, and Dfern92 are writing in accordance with our Developmental Biology course, as specified by the banner above. KMaher123 (talk) 04:02, 22 March 2013 (UTC)

Import
Data imported from User:KMaher123/Neural_fold. Still need to fix certain citations, wording and formatting. Therazzz (talk) 02:49, 3 April 2013 (UTC) KMaher123 (talk) 16:08, 4 April 2013 (UTC) Dfern92 (talk) 16:10, 4 April 2013 (UTC)

Richjoo
Although its hard to elaborate on a topic that’s so specific, I think that you guys did a really good job explaining what the neural fold is, its importance, and the mechanism of this process. The organization of the content was clear and cohesive. The pictures added to the article were excellent, and serves as a great aid to those who are struggling to understand the overall process. The first picture, for example, is really cool. The “Folding Mechanism” portion of the article is extremely well elaborated, and has good explanations and details. The inclusion of specific genes and molecules involved in the process was great. However, I think that you guys could more clear when explaining where the different cadherins (N and E) are located. Since we learned about this, I know where they are located, but I feel that for someone who has no idea this has to be explained explicitly. I also think that you guys could develop on the role of ephrin molecules and the Eph receptors that is mentioned at the end of the “Mechanism” portion. Adding the derivative structures that are formed throughout or after the process was really good, especially to establish links with other topics. In the “Diseases” portion of the article I like how the name of the condition and its effects were included, but I think it would be interesting to explain things in the molecular level. For example, how the lack of expression of a specific gene, failure in the cadherin, or something like that gives rise to the condition described. I made a few edits throughout the text, and a few sentences were not that clear. I did not change them so that I wouldn’t change what you guys meant, but here are these sentences:

"Only cells expressing the same kind of cadherin can bind to each other; since the peaks of the neural folds both express N-cadherin, they are able to merge into a continuous sheet of cells.”

“Since all of the cells of the neural plate are expressing this same type of cadherin, they are able to adhere to each other; similarly, when the cells at the peaks of the neural folds come in proximity with each other, it is this affinity for similar cadherin molecules that allows these cells to bind to each other.”

But as I said earlier, excellent figure choices and maybe another one could be added on the disease section. I also liked how you guys had plenty of wikilinks throughout the text. A few more “see also’s” could be included. Given the difficulty of the topic, great job! Richjoo (talk) 18:37, 13 April 2013 (UTC)

Tadala.jumbe
Hey guys, this article is really great. I spent a lot of time trying to find places where I could expand, but the information you provided is plenty expansive enough. There's a ton of information for this specific topic; I think that's great. The organization and flow is very good. I would just say the overall tone sounds a bit "smarter" than usual for a wikipedia page. I know Professor Hake wanted us to use layman's terms. It's very hard to do that with a topic that is so complex. However, there are a few of these situations in your article. For instance: "The molecular mechanism behind this process lies in the modulation of bone morphogenic proteins". I think modulation can be changed to something simpler. Other than a few of those instances, I can't seem to find anything else that needs to be changed. This is simply amazing. Great work. Tadala.jumbe (talk) 12:22, 14 April 2013 (UTC)

Hegarty.michael.c
"The neural fold is a structure that arises during neurulation in the embryonic development of both birds and mammals among other organisms"

Words like involution in the intro might be a little dense for the average non-biology student Wikipedian, I would consider rephrasing with simpler terms so the average reader can understand, especially in the intro. "The folds give rise to neural crest cells, as well bringing about the formation of the neural tube." <--I think this sentence is a little bit awkward sounding. The picture you included of the neural fold in a chick embryo is awesome.

I was a little confused by this: "The thumbnail below shows this process, as well as the subsequent formation of the neural crest cells and the neural tube, which arise from the joining of the neural fold" --> because in the previous sentence you are talking specifically about the microtubule polymerization, so I more expected to see a picture related specifically to that. Perhaps you could reorganize that paragraph so its more clear that the picture is really just showing you how the fold originates. This also makes me realize that I think the way the microtubule polymerization was mentioned felt just a bit vague, and I think thats why I expected to see a diagram to make it more clear ( thinking ″from a non-biology student perspective).

"The formation of the neural fold is initiated by the release of calcium." --> Do you know where is the calcium released from?

"These cells are held together by cadherin (specifically E-cadherin), a type of intercellular binding protein." --> I think this sentence is a great example of explaining the biology while also clarifying a dense term like cadherin into simpler terms, good job, and try to do this more!

It may not be necessary, but consider expanding the "Derivative Structures" subsection, for example you could maybe give a short description of what mesenchymal cells are, it doesnt have to be super detailed of course, but I think some more examples could be nice.

In the diseases section you use the term 'neuropore' I don't think its mentioned previously, I think it could help the reader if you explain what it is or, mention it earlier since I imagine it relates to the previous parts of your article

A good critique someone gave our article was try to find pictures for the diseases section, I agree with them that most people want to see what the disease looks like anatomically or otherwise.

Overall, I think its very impressive how much you were able to include on such a specific topic. The photos you did include are great, and there are a lot of places in your article that demonstrate really great explanation for people who don't have strong biology background.forabettalorretta 02:07, 15 April 2013 (UTC) — Preceding unsigned comment added by Hegarty.michael.c (talk • contribs)

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