Talk:Orellanine

LD50
I added LD50 data, and a tiny bit of primary research: according to the literature, the LD50 of Cortinarius Speciocissimus and Orellanus mushrooms is 3 and 2 (freeze-dried) g/kg in mice. This would correspond to 30 and 20 g/kg for fresh mushrooms: more than 1 kg for an adult human. Only few mushroom hunters would eat their catch in such amounts, from which I conclude that either humans are more sensitive than mice, or it often takes more than 2 weeks to kill. I don't have enough background in toxicology to judge this. Han-Kwang 23:18, 6 July 2006 (UTC)


 * The LD50 of pure Orellanine in mice is LD50 = 12.5 mg/kg intraperitoneally and LD50 = 90 mg/kg orally. I don't see any data on how much a adult human can ingest, but by reading incidents about Cortinarius poisoning it is obviously significantly less than 2kg. Most poisonings occur when a cortinarius mushroom has been accidently intermixed with other mushrooms and then ingested.


 * The toxins latency time is extremely long regardless of the amount ingested it seems, in mice that were administered several times ld50 they still had a latency time > 2 days (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7195467&dopt=Citation). mic 01:00, 7 July 2006 (UTC)


 * How is there no antidote? What about antioxidants? -lysdexia 02:47, 5 March 2007 (UTC)
 * There is no direct antidote because the toxin, and how it works, is not completely understood. The anti-oxidant, like many other therapies, may help the body recover from the damage caused by the toxin but they don't counteract the poison. ( and )

External links modified
Hello fellow Wikipedians,

I have just added archive links to 1 one external link on Orellanine. Please take a moment to review my edit. If necessary, add after the link to keep me from modifying it. Alternatively, you can add to keep me off the page altogether. I made the following changes:
 * Added archive https://web.archive.org/20120204222456/http://kidney.med.gu.se/PhD/Johan%20Holmdahl%20spikblad.pdf to http://kidney.med.gu.se/PhD/Johan%20Holmdahl%20spikblad.pdf

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Cheers.—cyberbot II  Talk to my owner :Online 10:02, 14 February 2016 (UTC)

Structure
There is a double bond missing in the right-hand tautomer, the there should be two single-headed arrows instead of one double-headed arrow (which indicates resonance, not tautomerism)