Talk:Pantothenic acid

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Untitled
There is a substantial body of literature that argues for Vitamin A reduction of acne, and there are also documented cases of high-dose B vitamins /causing/ acne:  --crl620 04:49, 5 May 2006 (UTC)
 * The ref mention of B-vitamins was not about pantothenic acid David notMD (talk) 11:42, 1 June 2020 (UTC)

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Rewrite
This article needs a complete rewrite. There is little information actually pertaining to Pantothenic acid, and lots of random junk about Dr. Lit-Hung Leung's research.

Dr. Leung
The 'study' performed by Dr. Lit-Hung Leung is extremely vague, published in a rediculous journal, and used commonly to sell B5 pills. The wiki page reads like an infomercial:

"Though this study was done in 1997, news did not spread...however, by word of mouth and eventually the internet, success stories have came in by the thousands..."

Here's the Leung article:

It was published in the journal "Medical Hypotheses," which is described on their site as:

"Medical Hypotheses takes a deliberately different approach to peer review. Most contemporary practice tends to discriminate against radical ideas that conflict with current theory and practice. Medical Hypotheses will publish radical ideas, so long as they are coherent and clearly expressed. Furthermore, traditional peer review can oblige authors to distort their true views to satisfy referees, and so diminish authorial responsibility and accountability. In Medical Hypotheses, the authors' responsibility for the integrity, precision and accuracy of their work is paramount. The editor sees his role as a 'chooser', not a 'changer': choosing to publish what are judged to be the best papers from those submitted."

It looks like it's a journal without any review system.

Other Issues
Overall the data on the wiki are poorly cited and shallow.

The wiki lacks clear scientific evidence and has no sources (minus the link to "Coenzyme-A Technologies", a company selling skin products).

Legitimate and well regarded sources tend to disagree with some of the suggestions on the wiki page. The Pauling Institute describes pantothenic acid as helping to heal skin wounds, whereas the wiki article says that "Some users report that cuts heal very slowly."

Some key facts about pantothenic acid are missing, such as recent research, absorption as d-Calcium pantothenate, chemical structure, and metabolism. As Dan| says below, the information about metabolism and "part of Coenzyme-A" makes no sense. To answer Dan's question, the pantothenate is a CoA precursor: KEGG CoA Pathway

This article needs to be substantially rewritten.

Could someone please edit the painfully anthropomorphic "Insulin receptors are acylated with palmitic acid when they do not want to bind with insulin.[22] " Joel1947 (talk) 18:25, 17 November 2015 (UTC)

Yes about the want to part, change it to acylation decreases binding of insulin to its receptors. FeritTuzer (talk) 08:12, 26 January 2020 (UTC)

Older Talk
Regarding "It is also needed for proper and healthy growth of hair," is this here because certain shampoo companies say it's true or because it's actually the case? All I can find are suggestions that the use of this chemical in shampoos has no effect, eg - 203.132.90.8 03:39, 4 Jun 2005 (UTC)

From personal experience: it is actually the case.78.151.26.19 (talk) 03:02, 28 October 2015 (UTC)

"Specifically, it is part of coenzyme-A (CoASH) in the metabolism and transfer of carbon chains."
 * That sentence dosn't seem to make any sense. --Dan|(talk) 15:16, 6 August 2005 (UTC)

B5
Using B5 as a treatment to acne really does work. I myself have had amazing results from it, and I am also aware of several other successful cases. I can't agree or disagree with the reasoning behind it, but there is little point arguing its effectiveness having seen the dramatic changes it has had.

a Pantothenic Acid Based Dietary Supplement found effective for Acne Blemishes in an open-label study
Journal of Cosmetics, Dermatological Sciences and Applications, 2012, 2, 132-135 doi:10.4236/jcdsa.2012.23026

&type=journal

"Conclusions: The results from this study indicated that the administration of a pantothenic based dietary supplement in healthy human adults with mild to moderate acne vulgaris is feasible, safe and well tolerated. Secondary analysis shows that administration of the study agent significantly reduced global facial blemishes. Further randomized, placebo-controlled trials are warranted."

thiamine—1.5 mg, riboflavin—1.7 mg, niacin—20 mg, pyridoxine—2 mg, folic acid—400 mgc, cyanoco-balamin—6 mcg, biotin—300 mcg, pantothenic acid— 2.2 g and L-carnitine—733.3 mg. : half of these a day

slightly relevant to the article

Prescription?
From the article, under disputed uses -> acne

"few if any dermatologists prescribe high-dose pantothenic acid."

Admittedly, few dermatologists (or any doctors, for that matter) prescribe pantothenic acid, but isn't that simply because one cannot prescribe things like vitamins/mineral/herbal supplements? A deficiency in Vitamin C, for example, can produce scurvy, however doctors wouldn't be able to prescribe you Vitamin C. They would, most likely, recommend it.

Also, perhaps someone could add that while studies are scarce, a large amount anecdotal evidence seems to support pantothenic acid's positive effects on acne? —The preceding unsigned comment was added by 74.132.210.179 (talk) 03:37, 25 April 2007 (UTC).

Yes, doctors do prescribe vitamins. My doctor prescribed me vitamin C tablets for my knee ligaments, even though he said "The use of this is controversial". He meant I was wasting my time and his.78.151.26.19 (talk) 03:00, 28 October 2015 (UTC)
 * If he did not write a prescription or send it to a pharmacy, it was a recommendation. David notMD (talk) 13:48, 2 May 2017 (UTC)

Biological half-life of the Acid?
Ben. Ben-Natan (talk) 04:21, 18 November 2014 (UTC)

Hair care
The article says this stuff doesn't do anything for hair. This is just wrong. If I take pantothenic acid for two days my hair is thicker. My nails also grow noticeably faster, almost to the point where it's a nuisance.78.151.26.19 (talk) 02:55, 28 October 2015 (UTC)
 * There are no published human trials in the scientific literature (at least none come up from a search on pantothenic acid x hair). Basically, this means not proven or disproven. What is needed is a placebo-controlled, blinded trial of several months duration. Until then, anecdotal, as in "It works for me." is not sufficient. Same applies to any claims for pantothenic acid in shampoo or conditioner.David notMD (talk) 12:24, 3 March 2016 (UTC)

External links modified
Hello fellow Wikipedians,

I have just added archive links to 1 one external link on Pantothenic acid. Please take a moment to review my edit. If necessary, add after the link to keep me from modifying it. Alternatively, you can add to keep me off the page altogether. I made the following changes:
 * Added archive https://web.archive.org/20130513041905/http://chemistry.ewu.edu/jcorkill/SOAPCONT.HTM to http://chemistry.ewu.edu/jcorkill/SOAPCONT.HTM

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Dietary Reference Intakes
I am creating the same format for DRIs for all B vitamins. That is a U.S.- based system that identifies Estimated Average Requirements (EARs), Recommended Dietary Allowances (RDAs), Adequate Intakes (AIs) if there is not enough information to establish EARs and RDAs, and Tolerable Upper Intake Levels (ULs). Another major regulatory agency that has established ULs is the European Food Safety Authority (EFSA). ULs for both are provided, as they often differ. If there is a UL (for some vitamins none has been determined) then rationale is covered in a Toxicity section. In addition to DRIs, the U.S. also established Daily Value, using it on food and dietary supplement labels as % DV. DVs were based on older RDAs and as of 2016 have never been updated to reflect the newer DRIs. Thus, often a product that has 100% DV and greater than 100% RDA. Examples given for each vitamin. What I have written can be improved. It lacks EFSA or other major country RDAs. It lacks an estimate of what percentages of people are deficient - although that is often covered in a separate section on deficiency and consequences of deficiency. I am creating this Subject in all of the Talk pages of the vitamin entries I have edited. Comments and improvements are welcome. David notMD (talk) 12:16, 3 March 2016 (UTC)
 * All vitamins and nutritionally essential minerals being changed from Dietary reference intakes to Dietary recommendations, as that is not a USA-only term. European Union information being added. David notMD (talk) 20:38, 30 August 2017 (UTC)

Infobox Crosses & Checkmarks
I glanced at WikiProject_Chemicals/Chembox_validation, but I don't understand why many of those IDs are reported "changed", when they match the linked sites. --Diblidabliduu (talk) 20:53, 3 February 2018 (UTC)

Improving article
Working to bring article to be closer to state of completeness seen in B-class and GA vitamin articles. David notMD (talk) 11:39, 1 June 2020 (UTC)
 * Nominated for GA. Article as it exists is much shorter than other vitamins that are GA or B-class, but that is because there is much less in the way of science published about this vitamin, as deficiency in humans is near-impossible, and claims for the vitamin as a dietary supplement are not supported by reliable-source literature. Of the vitamins, this is the shortest article, and with the fewest references. David notMD (talk) 15:10, 3 June 2020 (UTC)