Talk:Progesterone/Archive 1

Progesterone as veterinary behavior modifying drug
I read an older reference that said giving progesterone to canids scrambled their definition of alpha critter giving the human an opportunity to retrain the assertiveness of the animal

this is not at the current veterinary merck manual thogh

MCAT
The Princeton Review MCAT course/workbook has a question asking if the Adrenal gland produces bost estradiol and progesterone. It only lists the corpus luteum and placenta as correct answers and shows the adrenal medulla as being wrong. I am not an advanced level doctor (trying to get into medical school)....The article states progesterone is made in the adrenal glands...is this the case but only in small amounts? (Same question for estrogen also... Yakob32 03:19, 30 August 2007 (UTC)Jacob Yakob32 03:20, 30 August 2007 (UTC)

why does levonorgestrel redirect here?
It's not clear to me why levonorgestrel redirects here. Is levonorgestrel just synthetic progesterone or is it an isomer or just similar in effect? Matt 18:13, 23 Dec 2004 (UTC)

--Levonorgestrel is a synthetic progesterone receptor agonist (aka progestin).

Synthesis: Conflicting Information With Testosterone Article
In Progesterone article: Progesterone, like all other steroid hormones, is synthesized from pregnenolone, a derivative of cholesterol.

In Testosterone article: Testosterone is synthesized from progesterone, the precursor of all steroid hormones and a derivative of cholesterol.

These appear to me to be conflicting or at least confusingly incomplete.


 * Progesterone is not a precursor of all steroid hormones and conflicting information seems to have been clarified.Ekem 03:28, 7 June 2006 (UTC)

Clearer wording needed
"Progesterone is thermogenic, raising the core temperature."

Could someone clarify what this is the core temperature of? It's probably referring to the body's temperature but that should be made explicit in the article. --Molimo 00:44, 12 December 2005 (UTC)

There should be a discussion on this page about the difference between biodentical human progesterone, horse progesterone, and drugs that are similar to progesterone but are not progesterone.

"necessary to be suspicious..." deleted
could have been reworded to be less subjective, but would still have been misleading. distinction between exogenous/endogenous progesterone could be made viz safety testing, with care to note major distinctions amongst exogenous progestins, i.e., 19 carbon/21 carbon (all of which carry degree of warning as carcinogens). but. as far as i know, there has been no "safety" testing on endogenous progesterone... Cindery 02:24, 13 August 2006 (UTC)

multiple sclerosis and (not natural )progestagenes
I have a feeling that worsening of my MS coincides with starting my period; which means dropping of my progestagene levels"? There also are leads with cholesterols and multiple sclerosis, so are cholesterol and progestagene connected (synthesis). Is there a connection between low progestagenes (or relative lows on progestagenes as compared to estragens?) Why do twice as many women suffer from multiple sclerosis as do men? Does this give as a clue?

membrane progesterone receptors
A recent article about membrane progesterone receptors: "Two unrelated putative membrane-bound progestin receptors, progesterone membrane receptor component 1 (PGMRC1) and membrane progestin receptor (mPR) beta, are expressed in the rainbow trout oocyte and exhibit similar ovarian expression patterns". --JWSchmidt 05:49, 5 November 2006 (UTC)

parental behavior and progesterone levels
There is a relationships between progesterone levels and paternal/maternal care in some animals. I'm wondering if anyone has any information which could be added?Mechasam 16:55, 6 March 2007 (UTC)

Reference for the Bioavailability section?
There is currently no reference for the Bioavailability section of this article.

The Bioavailability section states: "Natural progesterone" products derived from yams, do not require a prescription. Wild yams contain a plant steroid called diosgenin, which the human body cannot metabolize into progesterone. Diosgenin can only be chemically processed into progesterone in labs."

The author (John Lee) of What Your Dr. May Not Tell You About Menopause, and the manufacturers of Serenity: Natural Progesterone cream assert that natural progesterone cream can be absorbed by the body as progesterone. The ingredients of Serinity as listed as: Purified Water, Organic Aloe Vera Gel 200:1 Concentrate (Aloe Barbadenis), Vegetable Glycerin, Natural Progesterone USP (2.25%), Vegepure (Complex, Stabilized Vegetable Oil), Natural Vitamin E, Glyceryl Stearate (from plant), Stearic Acid (from plant), Cetyl Alcohol (from plant), PEG-20 Methyl Glucose Sesquistearate (from plant), Methyl Glucose Sesquistearate (from plant), Hyaluronic Acid (Natural Skin Moisturizer), NaPCA (Natural Skin Humectant), Xanthan Gum, Citrus Seed Extract (a natural preservative).

The product claims to contain natural progesterone USP, but makes no mention of yams.

I was hoping the information from which the Bioavailability section of this article was derived could clarify whether there are other "natural progesterone" products in addition to yam-based progesterone products.

The wording of the final sentence "Diosgenin can only be chemically processed into progesterone in labs." leaves me wondering if manufactures are chemically processing diosgenin into progesterone and adding it to the cream. Or whether the article intends to assert that chemically processed progesterone can not be delivered via cream.

Any/all feedback welcomed.

Thanks,

Marimara (talk) 05:44, 12 March 2008 (UTC)marimara


 * I have added a two citations to the bioavailability section in which demonstrate no increase in progesterone levels after treatment with diosgenin. Furthermore this reference suggests that phytoprogestins (plant derived substances with progestin mimicing effects) are if anything antagonists (which block the effects of progestins).  Finally the chemical conversion of diosgenin into progesterone is somewhat involved (six chemical steps) and I seriously doubt that cream manufactures are converting diosgenin into progesterone, and if they were, they would be in serious trouble with the FDA.  Cheers.  Boghog2 (talk) 18:06, 12 March 2008 (UTC)

Annually?
The final section in the article quotes: "Eventually, this could become a standard treatment for the many people suffering traumatic brain injuries annually." Do we mean here that it may be used for people who sustain at least one TBI per year? I imagine the inclusion of the word "annually" is an unnecessary reference to the fact that statistics are often compiled annually. If so, it should be removed. —Preceding unsigned comment added by 69.233.26.244 (talk) 06:18, 3 May 2008 (UTC)
 * I agree that the use of annually here did not make any sense.  I have revised the section and included citations which document the neuroprotective effects of progesterone in traumatic brain injury.   Cheers.  Boghog2 (talk) 10:58, 4 May 2008 (UTC)

Effects of progesterone on the periodontal tissues
As i was reading for a seminar related to the subject of hormones and the periodontium, i noticed a small contradiction with articles i had read and the information here concerning gingival tissue repair.

Here it is stated: "(Progesterone) assists in thyroid function, in bone building by osteoblasts, in bone, teeth, gums, joint, tendon, ligament and skin resilience and in some cases healing by regulating various types of collagen, and in nerve function and healing by regulating myelin."

In a good review article related to the subject (Effects of endogenous sex hormones on the periodontium – Review of literature, Australian Dental Journal 2005;50:(3):138-145) there is a list of the effects of progesterone on the periodontal tissues, which are mostly negative:

Effects of progesterone on the periodontal tissues:

• Increases vascular dilatation, thus increases permeability

• Increases the production of prostaglandins

• Increases PMNL and prostaglandin E2 in the gingival crevicular fluid (GCF)

• Reduces glucocorticoid anti-inflammatory effect

• Inhibits collagen and noncollagen synthesis in PDL fibroblast

• Inhibits proliferation of human gingival fibroblast proliferation

• Alters rate and pattern of collagen production in gingiva resulting in reduced repair and maintenance potential

• Increases the metabolic breakdown of folate which is necessary for tissue maintenance and repair

If the clause is referring to progesterones effects on osteoblasts in the alveolar bone, then there is no contradiction.

The article also stated many interesting points regarding the effects of progesterone in the menstrual cycle, for example: "During the luteal phase of the cycle, when progesterone reaches its highest concentration, intraoral recurrent aphthous ulcers, herpes labialis lesions and candida infections may also occur in women." and "As a result (of the effects listed before), significant gingival inflammatory changes have been documented in association with the menstrual cycle, and gingival inflammation seems to be aggravated by an imbalance and/or increase in sex hormones"

Actinomycetencomitans (talk) 19:25, 24 September 2008 (UTC)

There should be a redirect from P4
I don't know how to do this, but I believe that the article P4 should have the option to redirect here, as progesterone is often short-formed to simply P4 —Preceding unsigned comment added by 99.255.162.25 (talk) 19:03, 28 April 2009 (UTC)


 * I agree. --Josta59 (talk) 18:52, 11 June 2009 (UTC)


 * The disambiguation page P4 (Pregn-4-ene-3,20-dione) now has a link to progesterone. Cheers.  Boghog2 (talk) 20:36, 11 June 2009 (UTC)

Citation #7 is no longer available. Thanks.

~Mike

Hi! Can it be used to enlarge breasts in women?
--MathFacts (talk) 15:38, 28 January 2010 (UTC)

Why not. --24.6.228.145 (talk) 01:52, 4 September 2010 (UTC)

NON-working Link
29) a b c Columbia Laboratories, Inc. (November 2004). "Prochieve (progesterone gel)" (PDF). http://www.prometrium.com/pdf/Patient_PatientInformation/Prometrium_Patient_Information.pdf. needs to be fixed UGAcodon (talk) 23:15, 2 July 2010 (UTC)

http://www.prometrium.com/pdf/Prometrium_Patient_Information.pdf this is the working link. UGAcodon (talk) 23:17, 2 July 2010 (UTC)

Medical Applications Section - Progesterone Compared to Progestins
The text reads: ''Medical applications The use of progesterone and its analogues have many medical applications, both to address acute situations and to address the long-term decline of natural progesterone levels. Because of the poor bioavailability of progesterone when taken orally, many synthetic progestins have been designed. However, the roles of progesterone may not be fulfilled by the synthetic progestins, which, in some cases, were designed solely to mimic progesterone's uterine effects.''

Please comment here regarding adding a discussion citing secondary sources which compare the roles of progesterone to other progestins. If there are no objections, it will be added. UGAcodon (talk) 23:36, 2 July 2010 (UTC)


 * Oppose – this is a highly controversial topic that is more appropriately covered here. Boghog (talk) 07:29, 3 July 2010 (UTC)
 * The initial statement needs a reliable source. I'm not sure what's being asked - how are the molecules being compared?  Any source used would need to be explicit in what it's comparing.  It would be inappropriate to take a source on a progestin, and a separate source on progesterone, and say "X is better than Y".  Particularly inappropriate would, I agree, be working towards the viewpoint that progesterone is better because it is natural or bioidentical.  WLU (t) (c) Wikipedia's rules: simple/complex 21:56, 4 July 2010 (UTC)

Source

 * ; there is a 2008 reprint that isn't free full access . WLU (t) (c) Wikipedia's rules: simple/complex 22:20, 4 July 2010 (UTC)


 * Thanks for the source. I have added it to the article to support the statement about synthetic progestins improved bioavailability.  Furthermore I have deleted the vague and unsupported statement that "the roles of progesterone may not be fulfilled by the synthetic progestins". Boghog (talk) 19:20, 6 July 2010 (UTC)

Progesterone from the female ovum attracts sperm to egg cell by progesterone gradients
Thanks for the edits on my expansion on the Cat Spar Channels research. Now that receptors for progesterone have been detected and located in the sperm, I also wanted to use the original articles for citation but had no access to the full papers so in good tradition used the secondary source from Science. Which included the papers by Lishko and others. I usually only cite full articles, when I have them available to read. It was not my attempt lower standards by not citing primary sources directly. Full access to the papers would further edits and expand as needed. — Preceding unsigned comment added by Osterluzei (talk • contribs) 20:12, 18 March 2011 (UTC)
 * No problem on the citations and thank you for adding this interesting and relevant material to the progesterone article. The Nature News article that you cited in turn cited the original papers. I must admit that I have not read the full papers either, but I did read the abstracts which gave me enough confidence to include them in the Wikipedia article. By the way, to format the citations, I used User:Diberri's Wikipedia template filling tool (instructions).  Given a PubMed ID, one can quickly produce a full citation that can be copied and pasted into a Wikipedia article. If you want to include the citation "in-line", be sure that the "add ref tag" option of the template tool is turned on. Cheers. Boghog (talk) 08:25, 19 March 2011 (UTC)

Medical applications
Under medical applications, it says that progesterone in the form of injection must be taken daily, when really it is taken only weekly. The cream form and maybe the pill form as well are the ones taken daily. 124.40.63.122 (talk) 05:13, 9 April 2011 (UTC)