Talk:SGLT2 inhibitor

This article could be updated to reference current trials (such as EASE II) which are looking at GLiflozins in Type 1 DIabetes:

https://clinicaltrials.gov/ct2/show/NCT02414958 — Preceding unsigned comment added by 165.225.80.115 (talk) 13:36, 18 March 2016 (UTC)

SGLT2 inhibitors and the heart
10.1161/CIRCULATIONAHA.116.021887 JFW &#124; T@lk  08:22, 7 September 2016 (UTC)


 * ... and heart failure in particular 10.1161/CIRCULATIONAHA.117.030012 JFW &#124; T@lk  20:13, 24 October 2017 (UTC)

As dapagliflozin blocks glucose resorption in renal tubules, it induces an increased urine output, with positive glucose in urine dipstick or lab tests. Dapagliflozine has the indication, besides T2DM, of Heart Failure: Could this dapagliflozine beneficial effect on HF come just from its diuretic effect, or is something more? Blessings +

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Halogens at the aromatic ring
No, they do not reduce metabolism by their electron affinity. They just block the position where enzymes will place a hydroxy group thus making the substance more soluble for excretion. And electron affinity is of no importance here. What is important here is the electronegativity and the polarizibility of the halogens. --FK1954 (talk) 14:41, 12 April 2019 (UTC)

electron affinity?
What is really meant with electron affinity in this article is the electronegativity. This is the electron-withdrawing force and a very different thing than electron affinity because electronegativity has to do with bonds; electron affinity ONLY with single atoms! --FK1954 (talk) 15:03, 12 April 2019 (UTC)

BMJ
10.1136/bmj.m4147 JFW &#124; T@lk  09:59, 22 November 2020 (UTC)