Talk:Sulfamethoxazole

-- Can someone take a look at the external link to the BrianDeer site? looks a little spammy and kind of controversial in it's slant, is that site authoritative enough for this type of page? —Preceding unsigned comment added by 72.25.192.4 (talk) 02:46, 31 December 2007 (UTC)

-- I'd like to ask you to remove the part below, cause as I understand it, wikipedia is not there to answer direct questions about adverse effects of drugs someone took. You should ask a physician or pharmacist about this. --evernever80.187.196.130 08:12, 23 August 2007 (UTC)

-- Also, I think that the "Main Complaint" part is ridiculous and in no way scientifically relevant. If your physician think you need the drug you should take it, if not you shouldn't get it all, wikipedia shouldn't be a forum for antibiotic drug addicts or whatever this is about. Thus the passage should be removed. --evernever80.187.196.130 08:12, 23 August 2007 (UTC) —The preceding unsigned comment was added by Special:Contributions/ (talk)

Untitled

 * Gone. Fvasconcellos (t·c) 14:14, 23 August 2007 (UTC)

Sulfamethoxazole - unexpected benefit? My 9 yr old daughter recently broke out in boils, was diagnosed with staph infection and given oral sulfamethoxazole. In addition to quickly healing up her sores, I noticed another benefit. My daughter is usually quite restless during the night, kicking, tossing and grinding her teeth. She often wakes up looking more tired than when she went to bed. After about the third day of taking the sulfamethoxazole, I noticed that she slept soundly and deeply, and far into the morning! That is highly unusual for her. I wonder what attribute of sulfamethoxazole contributes to this wonderful side effect? I'd guess my child would be considered "higly active" although I've had her tested for ADD/ADHD and she was not found to be either. Due to her newfound ability to sleep well, her daytime behaviour is also markedly changed for the better. Can anybody explain this?

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Bunny.Grp4, Policy.4nita, ElenaChan4. Peer reviewers: 3 icecreamcones, Hkay03, Smoshrefi3, JKwood$3.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 10:25, 17 January 2022 (UTC)

Structure wrong?
The Structure differs from what I found during a brief research. It seems improbable having a C involved in two double bonds and one single bonds--84.148.117.73 13:51, 26 January 2006 (UTC)


 * New structure uploaded. --Shaddack 21:41, 26 January 2006 (UTC)

Avoid sunlight?
I was curious as to why on the pill box label it says to avoid prolonged exposure to sunlight while taking this medication. Should it be noted in the article? JudgeOmega (talk) 02:14, 23 April 2009 (GMT)

Question about this medication
Does this medication have sulfer in it? Because I am allergic to sulfer medication. —Preceding unsigned comment added by 64.138.210.141 (talk) 01:28, 24 July 2009 (UTC) Soccer is awesome — Preceding unsigned comment added by 108.89.108.171 (talk) 22:45, 4 November 2013 (UTC)

11/4/15 The intended focus of the edits was to
1) verify the authenticity of information provided in the original article on sulfamethazole, specifically the introduction, side effects, and mechanism of action

2) clarify that sulfamethazole is discontinued as a drug

3) provide a more relevant overview of the drug given it is discontinued as a single drug but still being marketed and used as part of a combination drug product but without overlapping too much on the wiki entry on the combination drug Bactrim

4) provide the above information based on what intel that could be reliably found given the prescribing information for sulfamethazole us no longer attainable from the manufacturer or the FDA since it is a discontinued drug and given that paid tertiary resources like Lexi-comp and Micromedex were not acceptable for this assignment. Futhermore, we understood that compendia like Lexi-comp and Micromedex, were not original sources of drug information (since they derive much of their information usually by reinterpreting the PI) and therefore would not be the best source of information on this drug. We felt a package insert (PI) on the drug or even deriving information on the sulfamethazole API (active pharmaceutical ingredient) from the combination drug Bactrim's PI would be better since it is a primary resource or rather an original source of information. We also referenced NIH sponsored websites such as Toxnet which containing well referenced primary research and Pubchem. We also used information from a Canadian government sponsored drug database named drugbank and also double-checked if the FDA website had any additional information on sulfamethazole.

5) add a pharmacokinetics (PK) overview to the drug since PK is an important aspect of all drugs and this section was missing — Preceding unsigned comment added by ElenaChan4 (talk • contribs) 02:01, 7 November 2015 (UTC)

Peer Review
Here are some things to consider:

-Typo under side effects-missing an “e” in “therefore” -Under mechanism of action, explain what bacteriostatic means? Also explain further that sulfonamides are selective for bacteria because humans don’t synthesis folate but rather absorb folate from our foods. -Under absorption, may help to put % absorbed/bioavailability? -Under distribution explain tmax

Hkay03 (talk) 21:28, 7 November 2015 (UTC)Helen Kay, Christine Ly, Jason Kirkwood, Sean Moshrefi (Group 3)

Response to Peer Review
Thank you for you feedback.

For the PK section:


 * The term "Tmax" has updated accordingly. It is now defined as "time to reach maximum drug concentration in plasma."


 * Bioavailability data, however, has not been incorporated into this article since bioavailblity data (F) has not been found for sulfamethoxazole as a single API (active pharmaceutical agent). Although bioavailbility of sulfamethoxazole CO-FORMULATED with trimethoprim does exist as Bactrim's F, we felt using Bactrim's bioavaility data would be inaccurate for sulfamethoxazole. — Preceding unsigned comment added by ElenaChan4 (talk • contribs) 07:35, 9 November 2015 (UTC)

New study on resistance mechanisms
There's a new study out in Nature Communications today that details how Streptococcus is able to develop antibiotic resistance to sulfamaethoxazole. Surprisingly, it seems that it steals the inhibited folate compounds from its host! Silver seren C 01:03, 1 December 2022 (UTC)

Is it helpful with bacteria infection in your body such as endocarditis endocarditis
174.235.82.127 (talk) 18:03, 15 March 2024 (UTC)