Talk:Synovial fluid

Thixotropic or Rheopectic?; Pseudoplastic or Dilatant?
Isn't synovial / sinovial fluid thixotropic? One might imagine that's what keeps the joint from blowing apart in a high-g jump/fall... Seems it would be worth mentioning! 207.118.183.142 12:19, 16 January 2007 (UTC)

Synovial fluid is rheopectic, not thixotropic. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618490/

I'm not sure I agree. This is still a little troubling to me. Fairly authoritative sources seem to be giving contradictory information. Here's the first. A textbook.

1) A) Source: Page 221. https://books.google.com/books?id=PHTycR9_IYAC&pg=PA221&lpg=PA221&dq=synovial+fluid+dilatant&source=bl&ots=SHG94e3_xO&sig=8M-mDUiqlyTXNikn-xpxaAfxXVk&hl=en&sa=X&ved=0ahUKEwiR-fSv-5fMAhUMHD4KHTLsBcwQ6AEIejAS#v=onepage&q=synovial%20fluid%20dilatant&f=false B) Source's Conclusion: It says that synovial fluid is both Pseudoplastic and Thixotropic. C) Reasons to believe the source: it is a textbook, it attempts to describe the physical mechanism by which the fluid is non-newtonian, it appears to give actual data, it explains why rheumatoid and osteo-arthritis differ in relation to the proposed physical mechanism, it contains definitions of terms and those definitions are accurate. D) Reasons to distrust the source: It uses either the wrong units to describe viscosity (Pa*s) or it wrote the first sentence in the first paragraph incorrectly because it wrote that viscosity has units of Pa, which is just not true. It's proposed physical mechanism describing the non-newtonian nature of synovial fluid is either worded wrong or just appears to be wrong because it is counter intuitive. It claims the synovial fluid is shear thinning because as shear rate increases, the hyaluronic acid molecules align. Well, I just don't believe that molecules are more likely to align when they are moving more. So they seem to have made a mistake here. E) My opinion: the source seems authoritative because it is a textbook, but it clearly has at least some minor mistakes. It is moderate evidence that synovial fluid is Thixotropic and Pseudoplastic

2) A) Source: http://www.ncbi.nlm.nih.gov/pubmed/11673647 B) Source's Conclusion: Synovial fluid is Thixotropic C) Reasons to believe the source: it is a published paper with NCBI and it makes a modest amount of sense D) Reasons to distrust the source: it is worded a little poorly and can't easily be fully understood E) My opinion: It's modest but not good evidence that synovial fluid has at least the property of Thixotropy. This argument is strengthened by source 1.

3) A) Source: http://jbjs.org/content/45/6/1241 B) Source's conclusion: It suggests that synovial fluid is Thixotropic and Dilatant. C) Reasons to believe the source: It was published in JBJS. D) Reasons to distrust the source: It was published in 1965 and it contains typos. E) My opinion: It is modest but not good evidence that synovial fluid is both Thixotropic and Dilatant.

4) A) Source: http://www.orthopaedicsone.com/display/Main/Synovial+fluid B) Source's conclusion: Synovial fluid is both Thixotropic and Dilatant. C) Reasons to believe the source: It is well written and designed to explain how synovial fluid works, and it explains the biology and chemistry pretty well. D) Reasons to disbelieve the source: It's a commercial site and their priority is sounding good, not living up to academically rigorous standards. E) My opinion: It's pretty good but not great evidence that synovial fluid is both Thixotropic and Dilatant.

5) A) Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618490/ ; http://rsif.royalsocietypublishing.org/content/3/6/167.long B) Source's conclusion: (bovine) Synovial fluid is Rheopectic. C) Reasons to believe the source: It was published in NCBI and in TRS. The publication seems to be extraordinarily thorough. Bovine synovial fluid should not function differently than human synovial fluid, the author thinks so too, no one would research bovine synovial fluid unless it was relevant for humans. The article cites numerous sources that suggest that deteriorated synovial fluids have less viscosity, implying that well functioning synovial fluid is or can become more viscous when functioning properly. ie. Rheopectic D) Reasons to distrust the source: I can't think of any

6) A) Source: http://research-repository.uwa.edu.au/en/publications/the-inverse-thixotropic-behaviour-of-synovial-fluid(3352d9b1-b3a5-4e7c-95d1-5cc4a04d86e8).html B) Source's conclusion: Synovial fluid is Rheopectic C) Reasons to believe the source: Published in the JOR and cited on the University's website. D) Reasons to distrust the source: I don't have access to the full article.

Conclusion Source 5) seems best and calls it rheopectic, source 1) seems like it should be reliable too but calls it both thixotropic and pseudoplastic. Multiple sources call it both rheopectic and multiple sources call it rheopectic. These can't both be true. Multiple sources call it dilatant and only one source calls it pseudoplastic. These can't both be true either but there are more sources thinking it has dilatant properties. The rheopectic vs thixotropic question seems entirely unanswered from the numerous academic sources i could find but showed fairly one-sided evidence that it is dilatant. A fluid should be able to have any combination of a time-dependent property and a time independent property. So my conclusion is that synovial fluid is dilatant and either rheopectic or thixotropic. But clearly all of this information is inconclusive. — Preceding unsigned comment added by 96.249.10.252 (talk) 13:04, 18 April 2016 (UTC)

What is articular cartilage
synovial fluid reduces friction between the articular cartilage... I cannot find articular cartilage anywhere, is this right? —Preceding unsigned comment added by 65.113.122.130 (talk) 00:34, 22 September 2008 (UTC)


 * Yes, this is right. Any anatomy book will have this information.  Articular cartilage is attached to the end of long bones that are part of a synovial (diarthrotic) joint; it is made of hyaline cartilage. Articular cartilage prevents bone from rubbing against bone.FishAmplexity (talk) 23:58, 4 November 2011 (UTC)

What is the reason of deficiency of synovial fluid in human body ?
What is the reason of deficiency of synovial fluid in human body ? This needs to be answered. —Preceding unsigned comment added by 220.225.86.153 (talk) 05:52, 9 February 2010 (UTC)

Negative health effects of cycling?
Can more information be added to the article on the negative effects of regular cycling on the synovial joints? Does long-term regular cycling permanently wear out the cartilage, synovial tissue, synovial membrane or any other synovial part of the knee joints? Cartilage does not heal from damage, so any damage is permanent. Wsmss (talk) 13:37, 7 January 2011 (UTC)

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Basic anatomic concepts
In teaching Anatomy and Physiology some "core concepts" are pretty much agreed upon. One is that epithelial cells are the secretory cells of the body. Synovial fluid is produced by connective tissue cells, not epithelial cells, so might be thought of as an exception to the basic rule. However, when considered more carefully, it might be pointed out that synovial fluid is NOT secreted. Rather, the hyaluronan and lubricin are extruded from cell membranes and "pull" water from interstitial spaces by virtue of their extreme hydrophilic nature. The fluid is thus not produced by glands, epithelial structures. There can be a great deal of semantic quibbling about this idea - connective tissue by definition includes ground substance that is produced by non-epithelial cells after all. So, should the idea that synovial fluid is different from secretions in general be incorporated into this article? DStowens (talk) 23:28, 9 January 2016 (UTC)

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