Talk:Tandem mass spectrometry

November 2007

 * Tandem MS Experiments section - edited and updated this. There was some single MS info here, and I tried to present the information in a slightly clearer method.  Leafschik1967 03:17, 5 November 2007 (UTC)
 * Reorganized page - moved section with different tandem MS experiments closer to top of article. —Preceding unsigned comment added by Leafschik1967 (talk • contribs) 03:45, 5 November 2007 (UTC)

October 2009
In tandem mass spectrometry in space, the separation elements are physically separated and distinct, although there is a physical connection between the elements to maintain high vacuum. ??? the elements are physically separated but they are physically connected. please clarify! —Preceding unsigned comment added by 130.235.96.167 (talk) 10:18, 23 October 2009 (UTC)

Article restructuring
I cannot help but notice several shortcomings with this article. From even a quick read several issues stand out: (1) "In-source fragmentation" cannot be considered a technique of tandem mass spec. as no mass analysis has occured in the source. This section can stay but should appear after all other MS-MS techniques have been described. (2) The "newborn screening" section is only marginally relevant. What the article needs instead is a section dedicated on applications of tandem MS, where this information can appear. (3) A discussion on the usefulness of fragment spectra for structural elucidation of small molecular ions is missing. (4) I am quite surprised that none of the historical papers describing the various dissociation techniques are cited in the article nor appear in the bibliography.

I do find these issues to be rather serious and need to be amended. — Preceding unsigned comment added by 82.41.251.52 (talk) 20:59, 12 December 2012 (UTC)

I discovered this article while searching for how an ionization reaction actually takes place. While I am writing in this section, I find many shortcoming with regard to actual descriptions. I think it should be helpful if the ionization method is described. Once an ion has formed, then transfers, fragmentations, etc., become plausible. Even so, c- and z-fragmentation is a mystery to me and seemingly to Wikipedia. Overall, mass spectrometry is currently demanding a level of knowledge that I don't think is consistent with the objectives of Wikipedia. Again, I am only adding my comment to this section, but I could write this same criticism for other sections. Let me give an example of one kind of shortcoming. A reference to further information that requires a subscription to read. I have come to Wikipedia trying to find explanations for topics, not a source of references to them. Petedskier (talk) 16:15, 23 November 2022 (UTC)

January 2016
Could someone write an introduction? I would like to inform myself, but the article begins directly with detailed explanations without mentioning in the introduction what the difference between tandem and classical mass-spec is and why the tandem approach was invented. — Preceding unsigned comment added by 198.11.30.167 (talk) 30 January 2016
 * I added a few sentences to expand the lead. --Kkmurray (talk) 18:16, 31 January 2016 (UTC)