Talk:Targeted intra-operative radiotherapy

Concerns
We have a bunch of primary sources
 * http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)60837-9/abstract


 * http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)60837-9/abstract

And a bunch of links to the editors own website:
 * http://www.targit.org.uk
 * http://www.jayantvaidya.org/breast_cancer_surgeon/TARGIT_trial_results.html

Editor appears to be trying to promote themselves. Doc James (talk · contribs · email) 18:54, 18 May 2016 (UTC)

Edit request
User:Jsvaidya has acknowledged his COI and asked here for me to construct an edit request for him. This is the content he wanted to add.


 * TARGIT-A

The TARGIT-A trial was an international multicenter prospective randomised phase 3 clinical trial designed to test whether a single dose of targeted intraoperative radiotherapy could replace the usual 3-6 week course of postoperative radiotherapy. The first results found no difference in cancer control and TARGIT also caused less radiotherapy related toxicity than whole breast radiotherapy. The trial completed recruitment of 3451 patients in June 2012. The results, presented in the San Antonio Breast Cancer Conference in December 2012 2012 SABCS, Thursday 6 December, General Session 4 and later published, showed that that giving TARGIT at the time of lumpectomy, gives results similar to whole breast radiotherapy in terms of breast cancer control (particularly in ER PR positive cases), with fewer non-breast cancer deaths and a trend for lower overall mortality compared with conventional external beam whole breast radiotherapy. The results have been further clarified in the Red Journal.

The quality of life of patients who receive TARGIT is better than those who receive EBRT Full text PDF. Analysis of distance travelled by breast cancer patients for taking their radiotherapy found that TARGIT IORT radiotherapy during lumpectomy for breast cancer could save millions of travel miles & tonnes of CO2, plus free up thousands of hours for women with early stage breast cancer, every year. Full Text PDF. Video abstract.

A meta-analysis of randomised trials of partial breast irradiation (PBI) vs. whole breast irradiation (WBI) as part of breast conserving therapy demonstrated a reduction in non-breast-cancer and overall mortality. Full text and Audio Slides
 * TARGIT in context with other forms of Partial Breast Irradiation (PBI)


 * TARGIT-B (Boost)

TARGIT as a tumour bed boost: In conventional EBRT, the boost is delivered at the end of a complete course of EBRT. Clinical evidence suggests that boost radiation improves treatment outcome for breast cancer. With TARGIT the boost can be delivered intraoperatively without any delay and more precisely as compared to conventional EBRT. A multicenter clinical trial has demonstrated that the boost administered with IORT resulted in a lower than expected rate of local recurrence (1.73%) as compared to an EORTC study which used external boost radiation.

As a tumour bed boost, TARGIT has been found to have a better than expected effectiveness These results have prompted the inclusion of TARGIT boost as an option to EBRT boost in national clinical guidelines of many countries including Germany. Whether TARGIT is superior to an EBRT boost is being tested in a randomised trial IORT Boost TARGIT-B trial.

-- Jytdog (talk) 05:50, 19 May 2016 (UTC)
 * per ...many of these references seem to be trials...maybe mention reference #6 meta-analysis(but not all the above references)-but need more opinions-Ozzie10aaaa (talk) 20:04, 15 April 2017 (UTC)
 * We have a Cochrane review that comes to different conclusions. Would be good to par this down to just review articles. Doc James  (talk · contribs · email) 23:32, 15 April 2017 (UTC)
 * yes,much better!--Ozzie10aaaa (talk) 00:52, 16 April 2017 (UTC)

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