Talk:Tetrahydrodeoxycorticosterone

Translating into Russian
I'll translate it now without the usual recheck; seems to be a good article on first sight.. recheck later. Saw the mention of it at the Schizophrenia Research Forum, here - the new findings may be mentioned in the article if needed. -- C opper K ettle  06:16, 5 November 2009 (UTC)

What 3-alpha-HSD?
What is the enzyme that produces it? There seems to be three pages at Wiki: Best regards, -- C opper K ettle  06:41, 5 November 2009 (UTC)
 * AKR1C4
 * 3alpha-hydroxysteroid dehydrogenase (B-specific)
 * 3alpha-hydroxysteroid dehydrogenase (A-specific)

Confusion regarding stereochemistry
Unfortunately there is confusion as to the stereochemistry around the 5-carbon. The endogenous steroid is most probably 5alpha. However, tetrahydrodeoxycorticosterone generally refers to 5beta. Therefore, the neurosteroid should be called "allotetrahydrodeoxycorticosterone." Most commonly it is abbreviated THDOC. So things are a mess. I have tried to fix as best I can. I removed the incorrect structure. A new structure with the 3alpha,5alpha stereochemistry will need to be added. Pentagron (talk) —Preceding undated comment added 15:10, 27 September 2010 (UTC).

On the seeming significant chance
…that this emphatic opening statement contains a typographical error being parroted about the web, I am going to follow chemisches Gefühl (i.e., instinct) and make the following bold edit. (Usual painstaking work here limited to note 12x higher number of hits for corrected name over uncorrected, and a good number of the uncorrected appearing in rebroadcasts of this apparent Wikipedia typo.) Here is the change (in a form familiar to those appreciating CAPA as a four letter word). Note, the bold of the name containing the error has been omitted in CHANGED FROM, for clarity:

CHANGE LOCATION: Tetrahydrodeoxycorticosterone, opening paragraph 1, sentence 1

CHANGED FROM: "Tetrahydrodeoxycorticosterone (3α,21-dihydroxy-5α-pregnan-20-one; THDOC), or more preferred allotetrahydr oxyc orticosterone, is an… "

CHANGED TO: "Tetrahydrodeoxycorticosterone (THDOC, 3α,21-dihydroxy-5α-pregnan-20-one, alternatively allotetrahydr oc orticosterone) is an… "

The additional non-typographic changes were, (i), moving the abbreviation to immediately follow the name it is abbreviating, and (ii) changing the original bolding of the name to italic and removing the phrase "more preferred". The former is self explanatory; the latter stems from the appearance of the THDOC acronym, prima facie, in the article citations (the "preferred" alternative being absent), and the 5x greater frequency of appearance of THDOC on the web over the alternative (Google search run, 8 June 2014). As well, there was the lack of verifiability of the comparative "more" or any statement or substantiation of who it is that prefers the alternative (by either spelling). Rather than tag all these ambiguities (e.g., and ), I made these further conservative edits. Please, revert if I have erred. Who knows, someone may actually prefer to call a tetrahydro-steroidal diol by the strange tetrahydroxy name. (If so cite, so I can pursue vindicta elsewhere.) Cheers.

CHANGED BY: Le Prof Leprof 7272 (talk) 06:17, 8 June 2014 (UTC)

Tags added for
…over reliance on primary sources, and on primary sources in the molecular biosciences (while making broad medical claims). Only 1 of 11 refs are secondary/tertiary, perhaps 2 (if self-referential Trends is accepted). So editors are actively interpreting significance of work and subject based on primary source reading/TIABs, to a degree discouraged at the encyclopedia. Also, added journal abbreviations in quick pass, prompted by the ridiculously overlong "official journal of the" that appeared more than once. Feel free to check these for accuracy to bibliographic norms in the neurosci area. Le Prof Leprof 7272 (talk) 06:17, 8 June 2014 (UTC)

The following are a list of a few of the many
…secondary citations that appear for at least the epilepsy side of this question. Note, Reddy is particularly prolific, and effort should be made to discern the preponderance of medical opinion by actively seeking reviews from other institutions/authors as well. Same for other therapeutic areas with tremendous literature presence by a single author or group. Le Prof Leprof 7272 (talk) 06:36, 8 June 2014 (UTC)
 * https://www.ncbi.nlm.nih.gov/pubmed/23477307
 * https://www.ncbi.nlm.nih.gov/pubmed/23216582
 * https://www.ncbi.nlm.nih.gov/pubmed/17993775
 * https://www.ncbi.nlm.nih.gov/pubmed/20160650
 * http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422425/
 * http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728472/#B187
 * http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356070/
 * http://www.ncbi.nlm.nih.gov/pubmed/21094889/
 * Reddy D. S., Rogawski M. A. (2012). “Neurosteroids – endogenous regulators of seizure susceptibility and role in the treatment of epilepsy (Chapter 77),” in Jasper’s Basic Mechanisms of the Epilepsies, 4th Edn eds Noebels J. L., Avoli M., Rogawski M. A., Olsen R. W., Delgado-Escueta A. V., editors. (New York, NY: Oxford University Press) 982–1000
 * http://www.dl.begellhouse.com/journals/7b004699754c9fe6,120884550b58eaad,1d1d001a28da2d16.html