Talk:Whipple's disease

question
Who is credited for discovering that Tropheryma whipplei causes Whipple's disease? ReasonableLogicalMan (Talk 20:32, 3 February 2008 (UTC)


 * seems to be the publication of relevance, although various groups were looking at bacterial rRNA prior to this result. JFW | T@lk  15:54, 4 February 2008 (UTC)


 * closes the circle: T. whipplei was detected in biopsies from Whipple's original 1907 patient! JFW | T@lk  15:58, 4 February 2008 (UTC)

Recent reviews
The most recent reviews on this condition are:
 * - Lancet Infect Dis 2008
 * - Curr Opin Gastroenterol 2008
 * - N Engl J Med 2007

Citing Didier Raoult at least once is going to be inevitable :-). JFW | T@lk  11:14, 14 November 2010 (UTC)


 * Primary source: immune reconstitution syndrome happens in about 10% and can be nasty: link. JFW &#124; T@lk  22:42, 6 December 2010 (UTC)

Expanding and updating
Now that I've started updating this I might as well give the article a good work-over and hopefully turn it into a useful resource. I still need to retrieve the Fenollar 2007 NEJM review. So far I've made expansions based on Schneider 2008. I will not use Marth & Schneider (2008, Curr Opin Gastroenterol)

By sections:
 * ✅ Signs and symptoms (could still add percentages, but probably meaningless)
 * Mechanism (expand from Schneider and NEJM)
 * Diagnosis (need expansion)
 * Treatment (ditto)
 * Epidemiology (could add something about prognosis)
 * History (could have more historical content still)

Further input from everyone much appreciated. JFW | T@lk  11:36, 15 November 2010 (UTC)
 * Treatment section is "correct but thin/wobbly." I may be able to work on appropriate WP:RSMED that address:
 * IRIS
 * Study for the Initial treatment of Morbus Whipple SIMW
 * Abx choice with ref to different sites of tissue dz, or abx allergies
 * PCR surveillance of CSF
 * prognosis
 * FeatherPluma (talk) 01:10, 31 October 2011 (UTC)

Nice work FeatherPluma! As you can see above I made this article one of my projects, and then I got distracted, possibly by an FAC elsewhere. I'll see what I can do to help, but sadly very busy in meatspace. With regards to the articles you mentioned, please bear in mind that we should be cautious with primary sources. JFW &#124; T@lk  11:45, 31 October 2011 (UTC)

Some inaccuracies, sources?
Looking through, there are some statements that seem inaccurate and some that are not properly sourced. Under the section "Diagnosis" - skin rashes are quoted as a clinical manifestation. I am not familiar with this as a symptom, and cannot find this in any source, including the one cited (a french article, there are many perfectly good English reviews to cite in an English encyclopedia...) I will now correct this. I will also post about any other corrections. Treatment is also out of date. — Preceding unsigned comment added by Ibenami (talk • contribs) 23:12, 17 July 2014


 * Hello - I believe the rashes are mentioned in an old source. I agree that the article is in need of updating; I've listed some reviews above but I never got round to improving the article.
 * Feel free to fix whatever is necessary and let me know if you need a hand! JFW &#124; T@lk  15:59, 23 July 2014 (UTC)

Review
10.1016/S1473-3099(22)00128-1 JFW &#124; T@lk  04:59, 23 September 2022 (UTC)